author: Richèl J.C. Bilderbeek date: 2021-07-15 autosize: true
https://github.com/richelbilderbeek/igp_presentation_20210715
| Age (years) | Incidence |
|---|---|
| 50-60 | 0.4% |
| 60-70 | 0.7% |
| 70-80 | 2.3% |
| 80+ | 12% |
Igl et al., 2010
38 citations
Höglund et al., 2019
Kierczak et al., unpublished
Quantitive trait associations, e.g. protein levels, are important.
Works well when:
Can we find novel associations using machine learning?
Novel == un(der)detected using existing methods
Lao, Oscar, et al. “Correlation between genetic and geographic structure in Europe.” Current Biology 18.16 (2008): 1241-1248.
Lao et al., 2008 figure 1
Ausmees, Kristiina and Nettelblad, Carl. “A deep learning framework for characterization of genotype data.” bioRxiv (2020)
Ausmees and Nettelblad, 2020 figure 3a
Ausmees, Kristiina and Nettelblad, Carl. “A deep learning framework for characterization of genotype data.” bioRxiv (2020)
Ausmees and Nettelblad, 2020 figure 3b
| Character | Full | What |
|---|---|---|
| G | Genomic | Works on genomic data |
| C | Convolutional | Works on processed data |
| A | Auto | Learns by itself |
| E | Encoder | to efficiently encode the data |
Can we find novel associations using GCAE?
Novel == un(der)detected using existing methods
Proof of concept:
library(plinkr)
set.seed(314)
mafs <- 0.49
n_individuals <- 1000
A phenotype that is completely unrelated to the SNPs investigated
class: small-code
snvs <- create_snvs(
n_individuals = 4
)
calc_random_phenotype <- function(snvs) {
stats::runif(nrow(snvs))
}
snvs$random <- calc_random_phenotype(snvs)
knitr::kable(snvs)
| snv_1a | snv_1b | random |
|---|---|---|
| A | A | 0.0988320 |
| A | C | 0.2714778 |
| C | A | 0.7665282 |
| C | C | 0.2246424 |
class: small-code
random_trait <- create_custom_trait(
phenotype = "random",
mafs = 0.49,
n_snps = 1,
calc_phenotype_function =
calc_random_phenotype
)
random_data <- create_demo_assoc_qt_params(
traits = random_trait,
n_individuals = n_individuals
)
knitr::kable(
cbind(
random_data$ped_table[, -seq(1, 6)],
random_data$phe_table[, 3]
)
)
| snv_1a | snv_1b | random |
|---|---|---|
| C | C | 0.4666161 |
| C | C | 0.3510843 |
| A | A | 0.9266955 |
| C | A | 0.9974184 |
| C | C | 0.4981833 |
| C | C | 0.4371469 |
| C | C | 0.3710171 |
| A | A | 0.4765347 |
| C | A | 0.8747569 |
| A | A | 0.0703521 |
| C | A | 0.5177573 |
| A | C | 0.7403552 |
| C | A | 0.6766470 |
| C | C | 0.3195054 |
| A | C | 0.6527457 |
| C | C | 0.2545512 |
| A | A | 0.4073478 |
| C | A | 0.8687714 |
| A | C | 0.9359008 |
| A | C | 0.7342456 |
| C | C | 0.4629348 |
| C | A | 0.9954340 |
| A | C | 0.4298082 |
| C | A | 0.5565240 |
| A | C | 0.2405035 |
| A | A | 0.2429802 |
| C | A | 0.4378420 |
| A | C | 0.9054450 |
| C | C | 0.0004699 |
| A | C | 0.5640251 |
| A | C | 0.8818015 |
| A | C | 0.5051586 |
| A | C | 0.8302418 |
| C | C | 0.4009614 |
| C | C | 0.9330289 |
| A | C | 0.1390164 |
| C | C | 0.5665199 |
| C | C | 0.8372669 |
| C | C | 0.5175253 |
| A | C | 0.2984122 |
| A | C | 0.3875989 |
| C | C | 0.6318162 |
| A | C | 0.1600651 |
| A | A | 0.5808374 |
| A | C | 0.7287619 |
| A | A | 0.9184051 |
| C | A | 0.9380222 |
| C | C | 0.0702222 |
| C | A | 0.9573446 |
| A | C | 0.4708177 |
| A | A | 0.2436554 |
| A | A | 0.6870006 |
| C | C | 0.6033164 |
| C | A | 0.5356131 |
| C | A | 0.0292049 |
| C | A | 0.4869139 |
| C | C | 0.2194685 |
| C | C | 0.6752314 |
| A | C | 0.2737835 |
| A | C | 0.0111437 |
| C | A | 0.6616764 |
| C | A | 0.9479069 |
| A | C | 0.8620828 |
| A | A | 0.7223205 |
| C | A | 0.6246416 |
| C | A | 0.2143780 |
| C | A | 0.8565959 |
| C | A | 0.4969844 |
| C | C | 0.2784219 |
| A | C | 0.5260534 |
| C | C | 0.8121509 |
| A | A | 0.0180577 |
| A | A | 0.2200433 |
| A | A | 0.0813889 |
| A | A | 0.4023108 |
| A | A | 0.1350695 |
| A | C | 0.3755708 |
| C | C | 0.4239408 |
| C | A | 0.2754110 |
| C | C | 0.9584926 |
| C | C | 0.7027859 |
| A | A | 0.1828515 |
| C | C | 0.9035468 |
| A | A | 0.1277749 |
| C | C | 0.8167092 |
| A | A | 0.2538690 |
| C | A | 0.0027642 |
| A | A | 0.1268870 |
| A | A | 0.6045920 |
| C | A | 0.9469801 |
| A | C | 0.1704597 |
| C | A | 0.8230466 |
| C | A | 0.0168202 |
| C | C | 0.0859954 |
| C | C | 0.4236687 |
| A | C | 0.7816329 |
| C | C | 0.9444947 |
| A | A | 0.5371656 |
| A | C | 0.1330566 |
| C | C | 0.2114321 |
| C | C | 0.5724692 |
| C | C | 0.5780750 |
| C | A | 0.9633829 |
| C | C | 0.9526718 |
| A | C | 0.5886201 |
| A | A | 0.0163122 |
| A | C | 0.0382191 |
| C | A | 0.3778935 |
| C | C | 0.0038855 |
| C | A | 0.0121057 |
| C | C | 0.4895431 |
| A | C | 0.0337622 |
| A | A | 0.2711655 |
| A | A | 0.1523292 |
| C | C | 0.3226183 |
| A | A | 0.4908241 |
| A | A | 0.7293634 |
| A | C | 0.0257039 |
| A | C | 0.7650239 |
| C | A | 0.5917298 |
| C | A | 0.6006035 |
| A | C | 0.5050879 |
| A | C | 0.6207248 |
| C | A | 0.3582780 |
| C | A | 0.6181159 |
| A | A | 0.7827187 |
| A | C | 0.8107463 |
| A | C | 0.3900908 |
| C | C | 0.5550675 |
| A | A | 0.8697689 |
| C | A | 0.6257760 |
| C | C | 0.1150237 |
| A | A | 0.2682994 |
| A | C | 0.6718922 |
| A | A | 0.4927311 |
| A | A | 0.3011806 |
| C | C | 0.9527706 |
| A | A | 0.7095233 |
| C | C | 0.1852366 |
| C | C | 0.0880095 |
| C | C | 0.9357250 |
| C | A | 0.5798597 |
| C | A | 0.9648490 |
| C | A | 0.8572698 |
| C | A | 0.3553385 |
| A | A | 0.9173626 |
| A | A | 0.1446935 |
| A | A | 0.3120757 |
| C | C | 0.8112037 |
| C | C | 0.4203017 |
| A | C | 0.8600740 |
| A | A | 0.4282796 |
| C | A | 0.7158796 |
| C | A | 0.9363899 |
| A | A | 0.8646936 |
| C | A | 0.7376986 |
| A | A | 0.4498195 |
| C | C | 0.9727773 |
| A | C | 0.9998425 |
| C | A | 0.1005272 |
| A | C | 0.9234042 |
| C | A | 0.6666076 |
| C | C | 0.7758992 |
| C | C | 0.9524245 |
| C | C | 0.6979056 |
| A | A | 0.5840827 |
| A | C | 0.4836001 |
| A | A | 0.5444697 |
| C | C | 0.6110389 |
| C | C | 0.4334467 |
| A | A | 0.3880146 |
| A | A | 0.9274434 |
| A | C | 0.9546580 |
| C | A | 0.2964629 |
| A | A | 0.8237353 |
| C | A | 0.3723806 |
| A | A | 0.2829903 |
| A | C | 0.4270406 |
| C | A | 0.6376593 |
| A | A | 0.7983570 |
| C | C | 0.9672294 |
| C | A | 0.9162136 |
| C | A | 0.0765617 |
| C | A | 0.0258274 |
| A | C | 0.7534460 |
| C | A | 0.6852524 |
| A | C | 0.5883287 |
| A | A | 0.3084476 |
| C | C | 0.9655612 |
| C | A | 0.4132219 |
| C | A | 0.1131252 |
| C | A | 0.9391504 |
| A | C | 0.1644022 |
| A | A | 0.6183585 |
| A | A | 0.2059833 |
| A | A | 0.0693161 |
| A | C | 0.6643047 |
| A | A | 0.6711986 |
| C | A | 0.1668075 |
| A | C | 0.4708659 |
| C | C | 0.0919447 |
| A | C | 0.7919454 |
| A | A | 0.2781073 |
| C | C | 0.7272416 |
| C | C | 0.8716855 |
| C | A | 0.6365015 |
| C | A | 0.4435521 |
| A | C | 0.4834481 |
| C | C | 0.0300629 |
| C | A | 0.0607565 |
| C | A | 0.7375413 |
| C | C | 0.1812268 |
| A | C | 0.9947233 |
| C | C | 0.2821435 |
| A | A | 0.5398953 |
| C | A | 0.6412068 |
| C | C | 0.7300088 |
| A | A | 0.1584773 |
| A | A | 0.6409074 |
| A | C | 0.5719852 |
| C | C | 0.6577698 |
| C | A | 0.4374673 |
| C | C | 0.0751168 |
| C | A | 0.8529090 |
| A | A | 0.1090336 |
| A | C | 0.4546626 |
| C | C | 0.0300427 |
| A | A | 0.5566143 |
| A | A | 0.3970274 |
| A | C | 0.2698140 |
| A | C | 0.2315345 |
| C | A | 0.3791137 |
| C | C | 0.1723093 |
| A | C | 0.3270362 |
| A | A | 0.0662876 |
| C | A | 0.6814550 |
| A | C | 0.3778047 |
| C | A | 0.7434023 |
| A | A | 0.9084648 |
| C | C | 0.7016574 |
| C | C | 0.9376146 |
| A | A | 0.3336255 |
| A | C | 0.0929231 |
| A | C | 0.3122960 |
| A | A | 0.6207482 |
| A | A | 0.0894140 |
| C | A | 0.4606120 |
| C | C | 0.9397063 |
| A | C | 0.2824683 |
| A | A | 0.4579554 |
| A | A | 0.5545835 |
| A | C | 0.0274181 |
| C | A | 0.0861547 |
| C | C | 0.9054060 |
| A | C | 0.4573563 |
| C | A | 0.6247406 |
| A | A | 0.5317663 |
| C | C | 0.3005938 |
| C | C | 0.1392729 |
| A | A | 0.2387616 |
| A | C | 0.1973084 |
| C | C | 0.6949484 |
| C | C | 0.5096948 |
| A | A | 0.4282848 |
| C | A | 0.1956676 |
| A | C | 0.6238853 |
| C | A | 0.4144428 |
| A | C | 0.3102670 |
| A | C | 0.8887328 |
| A | C | 0.0651954 |
| C | A | 0.8564127 |
| C | C | 0.8273041 |
| A | A | 0.1106101 |
| C | A | 0.5602648 |
| A | A | 0.5980109 |
| C | C | 0.8423409 |
| C | C | 0.7017333 |
| A | A | 0.3589375 |
| C | C | 0.4320411 |
| A | A | 0.3000680 |
| A | A | 0.2733039 |
| C | A | 0.9491902 |
| C | C | 0.6232438 |
| C | A | 0.5312069 |
| A | C | 0.8239511 |
| A | C | 0.6032270 |
| A | A | 0.9730198 |
| C | C | 0.2214207 |
| A | C | 0.7614851 |
| A | A | 0.3774368 |
| C | A | 0.9415224 |
| C | C | 0.8791712 |
| A | A | 0.9317173 |
| A | A | 0.2708685 |
| A | C | 0.8860205 |
| A | C | 0.5942857 |
| A | A | 0.5006507 |
| A | C | 0.7532699 |
| A | C | 0.5723658 |
| C | A | 0.6797457 |
| C | C | 0.8078294 |
| C | C | 0.9364945 |
| A | A | 0.7718503 |
| C | A | 0.4540436 |
| A | C | 0.5019872 |
| A | C | 0.4921837 |
| C | C | 0.6803712 |
| A | A | 0.6168179 |
| A | C | 0.1636093 |
| C | A | 0.1297464 |
| A | C | 0.0467316 |
| C | A | 0.7535574 |
| A | C | 0.2825315 |
| C | C | 0.5807508 |
| A | A | 0.6842838 |
| A | C | 0.3901077 |
| A | C | 0.2145733 |
| C | C | 0.5894208 |
| C | A | 0.0924488 |
| A | A | 0.5320341 |
| A | C | 0.0799992 |
| C | C | 0.5880456 |
| C | A | 0.4731335 |
| C | C | 0.1679480 |
| C | A | 0.7268089 |
| C | C | 0.9582479 |
| A | C | 0.4659862 |
| A | C | 0.3902719 |
| A | C | 0.5835994 |
| C | A | 0.9905484 |
| C | C | 0.3358580 |
| C | A | 0.6327363 |
| C | C | 0.9960790 |
| A | C | 0.6282579 |
| A | A | 0.5723205 |
| C | A | 0.0441136 |
| A | A | 0.5927434 |
| C | A | 0.1058055 |
| C | A | 0.6372760 |
| C | A | 0.1617871 |
| A | A | 0.7651678 |
| A | C | 0.2782309 |
| A | A | 0.2005444 |
| C | A | 0.2166562 |
| A | C | 0.1304861 |
| A | A | 0.4531552 |
| A | C | 0.6676283 |
| C | A | 0.9269115 |
| A | A | 0.4658814 |
| C | A | 0.5433713 |
| A | A | 0.7827837 |
| A | A | 0.4566344 |
| A | C | 0.8840102 |
| C | C | 0.6096605 |
| C | C | 0.2648941 |
| C | C | 0.4075191 |
| C | C | 0.8307778 |
| C | C | 0.7968948 |
| C | C | 0.1388298 |
| A | A | 0.9912732 |
| C | A | 0.7109792 |
| A | A | 0.4586971 |
| C | C | 0.9792808 |
| C | A | 0.6055506 |
| A | A | 0.7651727 |
| A | A | 0.3540049 |
| A | A | 0.8544064 |
| A | A | 0.3275437 |
| A | A | 0.6680774 |
| A | A | 0.6450859 |
| A | C | 0.1256085 |
| C | A | 0.9879515 |
| C | A | 0.3822403 |
| A | C | 0.5895235 |
| A | C | 0.6756132 |
| A | C | 0.5499352 |
| A | C | 0.2013024 |
| C | C | 0.4566241 |
| C | C | 0.6708180 |
| C | A | 0.3597837 |
| A | C | 0.5049601 |
| A | A | 0.5807733 |
| A | A | 0.2570299 |
| C | A | 0.0312179 |
| C | C | 0.4180220 |
| A | A | 0.6158686 |
| A | C | 0.3979164 |
| C | A | 0.2347665 |
| A | A | 0.7863461 |
| C | A | 0.7588834 |
| C | A | 0.6698301 |
| C | C | 0.0199496 |
| A | A | 0.3171380 |
| C | C | 0.7460284 |
| C | A | 0.8814165 |
| C | A | 0.9444794 |
| C | A | 0.6895219 |
| A | A | 0.8037568 |
| A | C | 0.6065219 |
| A | A | 0.5186909 |
| A | A | 0.3691207 |
| C | A | 0.7582214 |
| C | C | 0.4658594 |
| C | C | 0.0109562 |
| A | A | 0.0402317 |
| C | C | 0.3225180 |
| A | C | 0.3721057 |
| A | A | 0.8311548 |
| A | C | 0.7403355 |
| A | A | 0.2121572 |
| A | A | 0.9137420 |
| C | C | 0.5756018 |
| A | C | 0.6160652 |
| C | C | 0.6574057 |
| C | C | 0.4914116 |
| C | A | 0.2492873 |
| C | C | 0.1104924 |
| A | A | 0.5445646 |
| C | C | 0.4836012 |
| A | A | 0.7877096 |
| C | A | 0.6815864 |
| A | C | 0.5830562 |
| A | C | 0.2364739 |
| C | C | 0.8665226 |
| C | C | 0.1136608 |
| A | C | 0.8163246 |
| C | C | 0.0798466 |
| C | C | 0.5734623 |
| C | C | 0.1143040 |
| A | C | 0.5521747 |
| C | C | 0.7928454 |
| A | C | 0.3337094 |
| C | C | 0.4243316 |
| C | A | 0.5178803 |
| A | A | 0.2550578 |
| C | A | 0.9746749 |
| A | C | 0.4399638 |
| C | C | 0.8821483 |
| A | C | 0.5132134 |
| C | A | 0.8709597 |
| A | A | 0.7688647 |
| C | C | 0.9730690 |
| A | A | 0.6724718 |
| A | A | 0.0793417 |
| A | A | 0.0568489 |
| C | C | 0.5389315 |
| C | A | 0.7198852 |
| A | C | 0.8596539 |
| C | A | 0.3299948 |
| C | A | 0.1809232 |
| C | A | 0.1541132 |
| A | C | 0.4853563 |
| C | A | 0.0763109 |
| A | A | 0.6944921 |
| A | C | 0.0913871 |
| A | C | 0.2556522 |
| C | A | 0.5825426 |
| C | C | 0.3350374 |
| A | C | 0.0817167 |
| A | C | 0.0326506 |
| A | C | 0.3916646 |
| A | A | 0.3329409 |
| A | A | 0.4059414 |
| A | A | 0.3480986 |
| A | A | 0.5644677 |
| A | C | 0.0820233 |
| C | C | 0.7641447 |
| C | C | 0.9782927 |
| A | C | 0.6282667 |
| C | A | 0.2604343 |
| A | A | 0.1055512 |
| C | C | 0.3294907 |
| A | A | 0.2784329 |
| A | C | 0.3182845 |
| A | A | 0.4178078 |
| A | A | 0.3412568 |
| A | C | 0.4434163 |
| C | A | 0.0523547 |
| C | C | 0.8839304 |
| A | C | 0.0279326 |
| C | C | 0.9090986 |
| C | C | 0.7269895 |
| A | C | 0.5814303 |
| A | A | 0.5198086 |
| A | A | 0.9312780 |
| A | C | 0.8720374 |
| C | C | 0.0802594 |
| A | C | 0.6709002 |
| A | C | 0.9502418 |
| C | C | 0.4284022 |
| C | C | 0.9457046 |
| A | C | 0.1184846 |
| C | C | 0.3919949 |
| A | A | 0.7434794 |
| A | C | 0.5504710 |
| A | C | 0.1252938 |
| A | C | 0.8128436 |
| A | A | 0.0324762 |
| C | A | 0.6587953 |
| C | A | 0.5446679 |
| C | A | 0.5077797 |
| A | A | 0.7111439 |
| A | C | 0.2926608 |
| C | C | 0.9292295 |
| A | A | 0.5777770 |
| A | C | 0.0705725 |
| A | A | 0.0911942 |
| A | C | 0.2016614 |
| C | C | 0.3770013 |
| C | C | 0.5488359 |
| C | A | 0.4962836 |
| C | A | 0.9188033 |
| C | A | 0.7398807 |
| C | A | 0.7661714 |
| C | A | 0.2307042 |
| C | C | 0.6085597 |
| A | C | 0.2730960 |
| A | C | 0.9367553 |
| A | C | 0.4768693 |
| A | A | 0.8828825 |
| C | A | 0.5600388 |
| A | A | 0.7312513 |
| C | C | 0.2443317 |
| A | A | 0.7024435 |
| A | A | 0.4544640 |
| C | C | 0.8928226 |
| C | A | 0.4014438 |
| C | C | 0.8794568 |
| A | C | 0.3005931 |
| C | A | 0.1992199 |
| C | C | 0.0891043 |
| C | A | 0.4610701 |
| C | A | 0.5419761 |
| A | A | 0.1031305 |
| A | A | 0.8874168 |
| C | A | 0.1115674 |
| A | C | 0.7893450 |
| C | A | 0.1685595 |
| A | A | 0.3102403 |
| C | C | 0.4486753 |
| A | A | 0.7870413 |
| A | C | 0.3145313 |
| C | A | 0.7487236 |
| C | A | 0.9384275 |
| A | C | 0.9735567 |
| A | C | 0.3490794 |
| C | A | 0.3031048 |
| C | C | 0.5282730 |
| A | A | 0.5894396 |
| A | C | 0.7473248 |
| A | C | 0.2220238 |
| A | A | 0.5627885 |
| C | A | 0.3863824 |
| C | A | 0.5601803 |
| C | C | 0.2104119 |
| A | C | 0.5909070 |
| C | A | 0.1891368 |
| C | C | 0.2782372 |
| C | C | 0.7389831 |
| A | C | 0.0935567 |
| A | A | 0.1592087 |
| A | C | 0.2916470 |
| A | C | 0.7679305 |
| A | A | 0.5165332 |
| A | A | 0.0532552 |
| C | A | 0.3616485 |
| C | A | 0.6980632 |
| C | A | 0.7042008 |
| C | A | 0.0180456 |
| C | A | 0.4890411 |
| C | C | 0.3586478 |
| C | C | 0.7681677 |
| C | A | 0.7762700 |
| C | C | 0.9220175 |
| A | C | 0.2605463 |
| A | A | 0.6112005 |
| A | C | 0.5194468 |
| C | A | 0.9498760 |
| A | C | 0.9781126 |
| A | C | 0.4260136 |
| A | A | 0.9400258 |
| C | A | 0.0753193 |
| A | C | 0.6347329 |
| A | A | 0.1111704 |
| A | C | 0.9178106 |
| A | A | 0.0084370 |
| A | C | 0.7032672 |
| A | C | 0.6268811 |
| A | C | 0.7864589 |
| C | C | 0.2446179 |
| A | C | 0.8149701 |
| A | A | 0.5030566 |
| C | C | 0.6979812 |
| A | C | 0.7457462 |
| C | A | 0.4749425 |
| A | A | 0.9244362 |
| C | C | 0.8343865 |
| A | C | 0.4354053 |
| A | C | 0.4199613 |
| A | A | 0.7842396 |
| C | A | 0.4967197 |
| C | A | 0.4116587 |
| C | A | 0.2135292 |
| C | C | 0.7614026 |
| A | C | 0.9789993 |
| A | A | 0.6061888 |
| A | C | 0.6241813 |
| C | A | 0.8388331 |
| C | C | 0.7525550 |
| C | C | 0.3925327 |
| A | A | 0.8604693 |
| C | A | 0.3459759 |
| A | A | 0.0545327 |
| C | C | 0.8017420 |
| C | A | 0.9695920 |
| C | C | 0.1236853 |
| A | A | 0.9120288 |
| A | A | 0.3156028 |
| A | A | 0.8655264 |
| C | C | 0.1944189 |
| A | C | 0.7597411 |
| C | A | 0.7116087 |
| A | A | 0.3538896 |
| A | A | 0.2582500 |
| C | A | 0.8361822 |
| C | A | 0.7681128 |
| C | A | 0.1944977 |
| A | A | 0.8549429 |
| C | C | 0.0231320 |
| A | A | 0.3286483 |
| A | A | 0.6407425 |
| A | A | 0.8321432 |
| A | A | 0.6892191 |
| A | C | 0.5677826 |
| C | C | 0.3923747 |
| C | C | 0.1019067 |
| A | C | 0.7111376 |
| A | C | 0.1782497 |
| A | A | 0.1330976 |
| A | C | 0.6104559 |
| C | C | 0.5210718 |
| C | C | 0.4700686 |
| C | A | 0.3273444 |
| C | A | 0.3160120 |
| C | A | 0.1786410 |
| C | A | 0.0658570 |
| C | C | 0.4093793 |
| A | A | 0.6046722 |
| A | C | 0.0858282 |
| C | A | 0.3388073 |
| A | C | 0.3834126 |
| C | A | 0.0116835 |
| A | A | 0.0112445 |
| C | A | 0.4121569 |
| A | C | 0.9247135 |
| A | C | 0.1454897 |
| A | A | 0.2454147 |
| A | A | 0.9511524 |
| C | A | 0.6405375 |
| C | A | 0.2474059 |
| C | A | 0.3827176 |
| A | C | 0.3558224 |
| A | C | 0.0385165 |
| C | C | 0.7631317 |
| A | A | 0.0603459 |
| A | C | 0.7562703 |
| C | C | 0.8110166 |
| C | C | 0.1020797 |
| A | C | 0.4861379 |
| A | A | 0.8026842 |
| A | C | 0.1012761 |
| A | A | 0.9824437 |
| A | C | 0.5367259 |
| A | A | 0.3918665 |
| C | C | 0.4767991 |
| C | C | 0.4829490 |
| A | A | 0.9996209 |
| C | C | 0.3729697 |
| A | C | 0.1410470 |
| A | A | 0.2062874 |
| C | C | 0.9618192 |
| C | C | 0.0906319 |
| C | A | 0.5334823 |
| A | A | 0.5464305 |
| C | C | 0.9904428 |
| A | A | 0.9420824 |
| A | C | 0.4738046 |
| C | A | 0.1177171 |
| C | A | 0.2939928 |
| A | A | 0.7020855 |
| A | A | 0.1635664 |
| A | A | 0.1304048 |
| A | C | 0.3013606 |
| A | A | 0.3560951 |
| A | A | 0.9182480 |
| C | C | 0.9419227 |
| C | C | 0.6407294 |
| C | A | 0.9975696 |
| C | A | 0.1684956 |
| C | A | 0.1338170 |
| A | C | 0.7395642 |
| A | A | 0.7951193 |
| A | A | 0.3942684 |
| C | C | 0.3185834 |
| A | A | 0.1769174 |
| A | C | 0.8473011 |
| A | A | 0.7013506 |
| A | A | 0.7514620 |
| A | C | 0.1314984 |
| A | C | 0.7492562 |
| C | A | 0.6941915 |
| A | A | 0.0894323 |
| C | A | 0.2023432 |
| A | C | 0.9676830 |
| A | C | 0.8427891 |
| A | A | 0.8668877 |
| C | C | 0.4233567 |
| A | A | 0.5595452 |
| C | A | 0.4989349 |
| A | C | 0.8534839 |
| A | C | 0.6549371 |
| A | A | 0.6801301 |
| C | A | 0.2197171 |
| A | C | 0.0720694 |
| A | C | 0.6260967 |
| A | A | 0.4657452 |
| C | A | 0.5047930 |
| A | C | 0.6344040 |
| C | C | 0.0371545 |
| C | A | 0.6377103 |
| A | A | 0.1216814 |
| C | A | 0.0817386 |
| C | A | 0.7859042 |
| C | C | 0.2358361 |
| A | A | 0.7904143 |
| A | A | 0.4276631 |
| A | C | 0.9634062 |
| A | C | 0.4589111 |
| A | C | 0.7922427 |
| A | C | 0.2395715 |
| A | A | 0.2957950 |
| A | C | 0.5664626 |
| A | C | 0.3977834 |
| A | C | 0.7897962 |
| C | A | 0.7960711 |
| C | A | 0.5024974 |
| A | C | 0.1899999 |
| C | A | 0.1612482 |
| A | A | 0.1777423 |
| A | A | 0.9264901 |
| A | A | 0.3763493 |
| C | A | 0.5371158 |
| A | A | 0.0746483 |
| C | C | 0.8766525 |
| A | A | 0.1646734 |
| C | A | 0.5599592 |
| A | A | 0.8225924 |
| C | C | 0.6737581 |
| A | A | 0.1107575 |
| C | A | 0.9393545 |
| C | C | 0.6835719 |
| C | A | 0.5665965 |
| A | A | 0.9557607 |
| C | C | 0.5076551 |
| C | A | 0.6653639 |
| A | C | 0.0002148 |
| A | A | 0.0426709 |
| C | A | 0.5900110 |
| C | C | 0.5154159 |
| C | A | 0.2601222 |
| C | A | 0.4304230 |
| C | A | 0.1899322 |
| C | C | 0.7844609 |
| C | A | 0.6725929 |
| A | A | 0.4455120 |
| C | A | 0.6318241 |
| A | A | 0.1208290 |
| C | C | 0.6405798 |
| C | C | 0.0772491 |
| C | A | 0.0075431 |
| C | C | 0.1039240 |
| A | A | 0.0486205 |
| A | A | 0.4838083 |
| C | C | 0.7950885 |
| A | A | 0.5251844 |
| A | A | 0.8911304 |
| C | A | 0.8988009 |
| C | A | 0.5750265 |
| A | C | 0.2756697 |
| A | A | 0.8558785 |
| C | A | 0.1155735 |
| C | C | 0.5339752 |
| C | A | 0.2779338 |
| C | A | 0.9846536 |
| C | A | 0.4794410 |
| A | C | 0.2742371 |
| A | C | 0.7986782 |
| A | A | 0.8771590 |
| A | A | 0.3869111 |
| C | A | 0.6041917 |
| A | C | 0.7879579 |
| C | C | 0.8875683 |
| C | C | 0.1976407 |
| C | A | 0.9041664 |
| A | C | 0.8137890 |
| A | A | 0.1112325 |
| C | A | 0.4248483 |
| C | A | 0.6160928 |
| C | C | 0.6551671 |
| C | A | 0.4247597 |
| C | C | 0.2352774 |
| C | C | 0.8606986 |
| A | C | 0.2716826 |
| A | C | 0.1273805 |
| A | A | 0.2708936 |
| C | C | 0.0139387 |
| C | A | 0.9731068 |
| C | A | 0.3391411 |
| A | A | 0.8744968 |
| A | C | 0.6225029 |
| C | C | 0.6996219 |
| C | C | 0.8130248 |
| C | A | 0.5553371 |
| C | C | 0.5842930 |
| A | C | 0.4082653 |
| C | C | 0.2432749 |
| A | C | 0.3091446 |
| A | C | 0.3561779 |
| A | C | 0.0928875 |
| C | C | 0.8022082 |
| C | C | 0.1010219 |
| A | C | 0.8901768 |
| A | A | 0.8534160 |
| A | A | 0.3722945 |
| C | C | 0.5155753 |
| C | C | 0.5727323 |
| A | A | 0.0770026 |
| A | A | 0.0305304 |
| A | C | 0.6693833 |
| C | C | 0.6647151 |
| C | A | 0.8616880 |
| C | C | 0.7976026 |
| C | C | 0.2079309 |
| C | C | 0.8157047 |
| C | C | 0.7375956 |
| C | A | 0.0621384 |
| C | A | 0.7466082 |
| A | A | 0.4936111 |
| C | A | 0.9351776 |
| A | C | 0.5385510 |
| A | A | 0.0314340 |
| C | A | 0.9989825 |
| C | C | 0.7983505 |
| C | A | 0.0426443 |
| A | A | 0.6620382 |
| A | C | 0.8996151 |
| C | A | 0.0917038 |
| A | C | 0.2327766 |
| C | C | 0.2236708 |
| C | A | 0.5038954 |
| C | A | 0.6588374 |
| C | A | 0.2690986 |
| C | A | 0.4553947 |
| A | C | 0.5775289 |
| C | C | 0.1020962 |
| A | A | 0.4610585 |
| C | C | 0.7774649 |
| A | C | 0.9293922 |
| A | A | 0.6641263 |
| C | A | 0.6705401 |
| A | A | 0.4327305 |
| C | C | 0.6703399 |
| C | C | 0.8812089 |
| A | A | 0.7050738 |
| A | A | 0.7593923 |
| A | A | 0.7045978 |
| A | A | 0.5074407 |
| C | C | 0.2840270 |
| A | A | 0.4745199 |
| A | C | 0.6338311 |
| A | C | 0.9185726 |
| C | A | 0.4434773 |
| A | C | 0.8463547 |
| A | C | 0.5151644 |
| A | A | 0.1037102 |
| C | C | 0.3982917 |
| A | C | 0.8519634 |
| C | C | 0.9701751 |
| C | C | 0.4188398 |
| A | C | 0.1870167 |
| A | A | 0.4019237 |
| C | C | 0.8302911 |
| C | C | 0.7966104 |
| A | C | 0.9825703 |
| C | C | 0.2527198 |
| C | A | 0.6009068 |
| C | A | 0.1913789 |
| A | C | 0.3528933 |
| C | A | 0.2112345 |
| A | C | 0.9879303 |
| C | C | 0.0699386 |
| C | C | 0.0699394 |
| A | C | 0.0221869 |
| A | C | 0.2304051 |
| C | C | 0.8442560 |
| C | C | 0.4411132 |
| A | A | 0.5321461 |
| A | A | 0.8815089 |
| A | A | 0.6678429 |
| A | A | 0.9270807 |
| A | C | 0.6148443 |
| A | C | 0.9492530 |
| A | A | 0.7123162 |
| A | A | 0.7222642 |
| A | A | 0.3332822 |
| C | A | 0.7988101 |
| C | C | 0.0464513 |
| A | A | 0.9517916 |
| C | A | 0.0534337 |
| C | A | 0.2499527 |
| A | C | 0.7470510 |
| C | A | 0.8186687 |
| C | A | 0.4447032 |
| C | C | 0.7206328 |
| A | A | 0.8637040 |
| C | C | 0.6374391 |
| A | A | 0.9580782 |
| A | C | 0.8273690 |
| A | C | 0.9498859 |
| A | A | 0.4806838 |
| A | C | 0.1679107 |
| A | C | 0.8089452 |
| C | C | 0.2103624 |
| C | A | 0.7600507 |
| A | C | 0.7592641 |
| A | A | 0.5046873 |
| C | A | 0.8910522 |
| A | A | 0.4673860 |
| A | A | 0.7400161 |
| C | C | 0.0743672 |
| A | C | 0.5748291 |
| C | A | 0.7306150 |
| C | A | 0.6962998 |
| C | C | 0.2244872 |
| A | C | 0.1923304 |
| C | C | 0.4086744 |
| A | C | 0.2392953 |
| C | C | 0.3710278 |
| A | A | 0.1518727 |
| A | C | 0.5966447 |
| A | C | 0.6562796 |
| A | A | 0.0506342 |
| C | C | 0.3896968 |
| C | A | 0.1389603 |
| A | C | 0.7537261 |
| C | C | 0.6082859 |
| A | C | 0.6611963 |
| A | C | 0.6317300 |
| C | A | 0.1050916 |
| C | A | 0.8477488 |
| A | C | 0.1766640 |
| C | A | 0.9001773 |
| C | A | 0.0394498 |
| C | A | 0.5863107 |
| C | C | 0.7970429 |
| C | A | 0.8111590 |
| C | C | 0.0725563 |
| C | A | 0.6473193 |
| C | C | 0.7732047 |
| A | C | 0.4574499 |
| C | A | 0.1931646 |
| A | A | 0.5412246 |
| A | A | 0.1321397 |
| C | A | 0.7389283 |
| A | A | 0.3900107 |
| C | C | 0.9087116 |
| C | C | 0.2238422 |
| A | A | 0.7497868 |
| A | A | 0.4241231 |
| A | C | 0.9054928 |
| A | C | 0.9787024 |
| A | A | 0.0189182 |
| A | C | 0.7707907 |
| C | C | 0.3104862 |
| C | C | 0.9808219 |
| C | C | 0.5706555 |
| C | A | 0.3304665 |
| A | A | 0.7558455 |
| A | A | 0.5256735 |
| C | A | 0.4503466 |
| A | A | 0.4755245 |
| A | C | 0.4897302 |
| A | A | 0.9932242 |
| C | A | 0.8762484 |
| C | A | 0.5656362 |
| C | A | 0.3998546 |
| C | A | 0.2375648 |
| C | C | 0.8907967 |
| C | A | 0.8139643 |
| A | C | 0.1614114 |
knitr::kable(assoc_qt(random_data))
| CHR | SNP | BP | NMISS | BETA | SE | R2 | T | P |
|---|---|---|---|---|---|---|---|---|
| 1 | snp_1 | 1 | 1000 | 0.01843 | 0.01278 | 0.002079 | 1.442 | 0.1496 |
No association is correctly detected.
Zhu, Zhihong, et al. “Dominance genetic variation contributes little to the missing heritability for human complex traits.” The American Journal of Human Genetics 96.3 (2015): 377-385. Additive phenotype ======================================================== class: small-code
snvs <- create_snvs(
n_individuals = 4
)
calc_additive_phenotype <- function(snvs) {
(rowSums(snvs == "C") / 10.0) +
runif(nrow(snvs), min = 0.0, max = 0.01)
}
snvs$additive <- calc_additive_phenotype(snvs)
knitr::kable(snvs)
| snv_1a | snv_1b | additive |
|---|---|---|
| A | A | 0.0038967 |
| A | C | 0.1040717 |
| C | A | 0.1007025 |
| C | C | 0.2061279 |
class: small-code
additive_trait <- create_custom_trait(
phenotype = "additive",
mafs = 0.49,
n_snps = 1,
calc_phenotype_function =
calc_additive_phenotype
)
additive_data <- create_demo_assoc_qt_params(
traits = additive_trait,
n_individuals = n_individuals
)
knitr::kable(
cbind(
additive_data$ped_table[, -seq(1, 6)],
additive_data$phe_table[, 3]
)
)
| snv_1a | snv_1b | additive |
|---|---|---|
| C | C | 0.2001345 |
| A | A | 0.0035830 |
| C | A | 0.1023847 |
| C | A | 0.1053521 |
| A | A | 0.0005797 |
| C | A | 0.1069706 |
| A | C | 0.1089242 |
| A | A | 0.0018606 |
| A | A | 0.0006008 |
| A | C | 0.1050057 |
| C | A | 0.1084381 |
| A | C | 0.1023191 |
| C | C | 0.2030954 |
| A | A | 0.0059369 |
| C | C | 0.2033870 |
| A | C | 0.1099877 |
| A | C | 0.1014320 |
| A | A | 0.0080159 |
| A | A | 0.0022211 |
| C | A | 0.1028064 |
| A | A | 0.0023147 |
| C | C | 0.2085766 |
| C | C | 0.2092915 |
| C | A | 0.1077363 |
| A | C | 0.1060595 |
| A | C | 0.1000014 |
| A | C | 0.1096937 |
| C | C | 0.2041953 |
| C | C | 0.2011429 |
| C | C | 0.2035675 |
| A | A | 0.0047397 |
| A | A | 0.0045488 |
| A | A | 0.0054612 |
| A | C | 0.1020763 |
| C | C | 0.2012229 |
| C | C | 0.2026017 |
| C | A | 0.1046448 |
| A | C | 0.1052374 |
| A | A | 0.0080201 |
| A | C | 0.1074549 |
| A | C | 0.1002790 |
| A | A | 0.0056149 |
| A | A | 0.0029349 |
| C | C | 0.2070543 |
| C | A | 0.1001834 |
| A | A | 0.0098399 |
| C | A | 0.1017337 |
| A | A | 0.0041087 |
| C | C | 0.2093328 |
| C | A | 0.1089980 |
| C | C | 0.2011987 |
| C | A | 0.1005397 |
| C | C | 0.2076037 |
| A | A | 0.0010833 |
| C | C | 0.2044853 |
| C | A | 0.1003411 |
| C | C | 0.2064810 |
| A | C | 0.1045995 |
| A | A | 0.0056039 |
| A | C | 0.1082579 |
| A | A | 0.0057842 |
| C | A | 0.1051864 |
| A | C | 0.1037307 |
| C | C | 0.2077717 |
| A | C | 0.1029206 |
| C | A | 0.1033148 |
| A | C | 0.1075623 |
| C | C | 0.2063942 |
| C | C | 0.2076909 |
| A | A | 0.0092659 |
| C | A | 0.1056850 |
| C | A | 0.1097527 |
| C | C | 0.2083913 |
| A | C | 0.1035066 |
| C | C | 0.2033116 |
| A | C | 0.1050027 |
| A | A | 0.0017325 |
| A | A | 0.0005382 |
| A | A | 0.0077776 |
| C | A | 0.1029726 |
| C | C | 0.2050786 |
| C | A | 0.1003037 |
| C | C | 0.2053894 |
| C | C | 0.2094487 |
| A | C | 0.1041370 |
| C | C | 0.2039290 |
| C | C | 0.2068436 |
| A | C | 0.1006486 |
| C | C | 0.2070922 |
| C | C | 0.2066137 |
| A | C | 0.1004581 |
| A | A | 0.0017768 |
| A | A | 0.0063865 |
| A | A | 0.0068809 |
| A | A | 0.0037155 |
| A | A | 0.0016965 |
| A | C | 0.1085090 |
| A | A | 0.0021160 |
| A | C | 0.1001600 |
| A | A | 0.0027507 |
| A | A | 0.0026556 |
| A | A | 0.0002404 |
| A | C | 0.1029901 |
| C | A | 0.1043545 |
| C | A | 0.1099595 |
| A | A | 0.0086970 |
| A | C | 0.1045438 |
| A | C | 0.1049376 |
| C | C | 0.2071166 |
| C | C | 0.2079192 |
| C | C | 0.2081927 |
| C | C | 0.2055672 |
| C | A | 0.1067905 |
| A | A | 0.0015151 |
| C | C | 0.2007278 |
| A | A | 0.0060519 |
| A | A | 0.0041687 |
| C | C | 0.2024370 |
| A | C | 0.1044643 |
| C | A | 0.1090913 |
| A | A | 0.0015422 |
| A | C | 0.1025600 |
| A | A | 0.0064843 |
| C | A | 0.1075814 |
| C | C | 0.2019401 |
| C | A | 0.1025182 |
| A | A | 0.0034234 |
| C | C | 0.2093051 |
| A | C | 0.1086873 |
| C | C | 0.2007415 |
| C | A | 0.1041916 |
| A | A | 0.0077269 |
| C | A | 0.1045826 |
| C | A | 0.1048819 |
| C | C | 0.2001348 |
| A | A | 0.0063951 |
| A | A | 0.0006930 |
| C | C | 0.2097524 |
| A | A | 0.0002169 |
| C | A | 0.1084613 |
| C | A | 0.1083236 |
| A | A | 0.0029324 |
| A | A | 0.0011612 |
| A | A | 0.0054296 |
| C | C | 0.2015380 |
| C | A | 0.1036786 |
| A | C | 0.1089022 |
| C | A | 0.1089866 |
| A | C | 0.1015136 |
| C | C | 0.2041375 |
| C | C | 0.2015008 |
| C | C | 0.2026065 |
| C | C | 0.2033848 |
| A | C | 0.1052731 |
| C | C | 0.2025727 |
| A | A | 0.0005389 |
| C | C | 0.2093132 |
| A | A | 0.0043518 |
| A | A | 0.0096246 |
| A | A | 0.0037314 |
| A | C | 0.1079498 |
| A | C | 0.1097988 |
| A | A | 0.0032608 |
| C | C | 0.2046164 |
| A | C | 0.1069920 |
| C | A | 0.1001034 |
| A | C | 0.1048619 |
| C | C | 0.2026475 |
| C | C | 0.2063604 |
| A | C | 0.1084121 |
| A | C | 0.1041226 |
| C | C | 0.2039830 |
| C | A | 0.1064859 |
| C | C | 0.2090100 |
| A | C | 0.1023748 |
| C | C | 0.2044626 |
| A | C | 0.1092510 |
| C | A | 0.1017601 |
| C | A | 0.1065368 |
| A | C | 0.1064021 |
| C | C | 0.2057010 |
| C | A | 0.1076512 |
| A | C | 0.1003910 |
| A | A | 0.0036809 |
| C | C | 0.2024031 |
| A | C | 0.1090589 |
| C | A | 0.1069486 |
| A | C | 0.1061878 |
| A | C | 0.1029161 |
| A | A | 0.0023220 |
| A | C | 0.1014354 |
| C | A | 0.1080553 |
| A | C | 0.1031640 |
| C | C | 0.2075213 |
| A | A | 0.0040311 |
| C | C | 0.2032586 |
| C | A | 0.1097486 |
| C | A | 0.1012034 |
| A | A | 0.0076690 |
| A | C | 0.1073132 |
| C | C | 0.2045700 |
| C | A | 0.1098273 |
| C | C | 0.2011183 |
| A | A | 0.0015650 |
| A | A | 0.0059164 |
| A | C | 0.1029541 |
| C | C | 0.2041919 |
| A | C | 0.1042958 |
| A | A | 0.0010377 |
| A | C | 0.1035567 |
| C | C | 0.2024033 |
| C | A | 0.1074836 |
| A | C | 0.1097111 |
| A | A | 0.0038766 |
| C | C | 0.2017587 |
| C | A | 0.1016002 |
| A | A | 0.0049921 |
| A | A | 0.0070670 |
| C | A | 0.1033418 |
| C | C | 0.2063053 |
| C | C | 0.2087062 |
| A | A | 0.0008121 |
| A | C | 0.1062835 |
| A | C | 0.1068736 |
| A | A | 0.0015615 |
| C | A | 0.1033098 |
| A | C | 0.1010805 |
| A | C | 0.1029935 |
| C | A | 0.1029169 |
| C | A | 0.1047229 |
| C | A | 0.1065302 |
| A | A | 0.0082923 |
| A | C | 0.1095570 |
| A | A | 0.0094658 |
| A | A | 0.0089069 |
| A | C | 0.1048502 |
| C | C | 0.2062819 |
| C | A | 0.1054871 |
| A | C | 0.1079688 |
| C | A | 0.1075643 |
| C | C | 0.2028836 |
| C | A | 0.1043019 |
| A | A | 0.0002519 |
| C | A | 0.1075941 |
| A | C | 0.1087524 |
| A | A | 0.0042368 |
| A | C | 0.1089094 |
| C | C | 0.2063222 |
| A | C | 0.1064506 |
| A | A | 0.0050273 |
| C | C | 0.2090311 |
| A | A | 0.0037761 |
| C | A | 0.1082944 |
| A | C | 0.1051513 |
| A | C | 0.1068148 |
| C | A | 0.1029368 |
| A | C | 0.1021110 |
| C | C | 0.2028452 |
| C | A | 0.1009362 |
| C | C | 0.2027872 |
| C | A | 0.1051931 |
| C | C | 0.2095383 |
| A | A | 0.0045381 |
| C | C | 0.2099808 |
| A | C | 0.1069918 |
| A | A | 0.0073257 |
| A | A | 0.0064326 |
| A | C | 0.1036158 |
| C | A | 0.1029028 |
| C | A | 0.1024084 |
| C | A | 0.1098565 |
| C | A | 0.1005166 |
| C | C | 0.2031574 |
| A | C | 0.1097027 |
| A | A | 0.0078638 |
| C | C | 0.2032503 |
| A | C | 0.1075915 |
| A | C | 0.1036569 |
| C | A | 0.1027754 |
| C | C | 0.2000502 |
| A | C | 0.1020861 |
| C | C | 0.2026240 |
| A | C | 0.1055614 |
| C | C | 0.2076808 |
| A | C | 0.1015924 |
| C | C | 0.2051292 |
| C | A | 0.1002043 |
| A | A | 0.0004281 |
| A | C | 0.1065349 |
| A | A | 0.0079634 |
| A | C | 0.1081532 |
| C | C | 0.2027335 |
| C | A | 0.1066254 |
| A | C | 0.1075581 |
| C | A | 0.1052134 |
| A | A | 0.0052006 |
| C | A | 0.1003758 |
| C | C | 0.2054060 |
| A | C | 0.1014441 |
| A | C | 0.1047099 |
| C | C | 0.2085333 |
| C | A | 0.1076920 |
| C | C | 0.2083775 |
| C | C | 0.2032598 |
| A | A | 0.0033421 |
| A | C | 0.1042887 |
| A | A | 0.0028927 |
| A | A | 0.0055347 |
| A | C | 0.1092204 |
| A | C | 0.1001152 |
| C | C | 0.2093101 |
| A | C | 0.1075800 |
| A | A | 0.0016423 |
| C | C | 0.2039244 |
| A | A | 0.0032759 |
| C | A | 0.1075292 |
| A | A | 0.0037327 |
| C | C | 0.2088403 |
| A | A | 0.0024771 |
| A | C | 0.1045607 |
| A | A | 0.0064402 |
| A | A | 0.0087025 |
| C | A | 0.1072772 |
| A | C | 0.1073439 |
| A | C | 0.1079637 |
| C | A | 0.1041916 |
| A | A | 0.0025665 |
| A | C | 0.1009521 |
| A | A | 0.0089158 |
| C | C | 0.2066248 |
| A | C | 0.1077897 |
| C | C | 0.2046282 |
| A | A | 0.0089321 |
| C | A | 0.1024962 |
| A | C | 0.1084776 |
| A | C | 0.1027256 |
| A | C | 0.1060330 |
| C | A | 0.1013844 |
| A | C | 0.1055542 |
| C | C | 0.2050387 |
| A | C | 0.1020484 |
| A | A | 0.0003270 |
| A | A | 0.0064196 |
| C | C | 0.2069516 |
| A | C | 0.1044548 |
| C | A | 0.1076580 |
| C | C | 0.2043757 |
| A | A | 0.0036577 |
| A | A | 0.0060534 |
| C | A | 0.1094668 |
| A | C | 0.1006972 |
| A | C | 0.1038206 |
| A | C | 0.1082395 |
| A | A | 0.0087275 |
| A | C | 0.1028011 |
| C | A | 0.1044975 |
| C | C | 0.2032320 |
| A | C | 0.1000925 |
| C | A | 0.1000832 |
| C | C | 0.2037938 |
| A | A | 0.0007316 |
| C | A | 0.1013913 |
| C | C | 0.2089102 |
| A | A | 0.0092961 |
| C | C | 0.2064432 |
| C | A | 0.1091472 |
| A | A | 0.0029493 |
| A | C | 0.1038467 |
| A | C | 0.1043683 |
| C | C | 0.2000977 |
| A | A | 0.0096264 |
| C | A | 0.1030810 |
| C | C | 0.2071391 |
| A | A | 0.0036449 |
| A | A | 0.0041078 |
| C | A | 0.1084572 |
| C | A | 0.1003942 |
| C | A | 0.1097737 |
| C | A | 0.1012496 |
| C | A | 0.1085659 |
| C | C | 0.2092190 |
| C | A | 0.1069667 |
| A | A | 0.0082523 |
| C | A | 0.1068874 |
| C | C | 0.2072094 |
| A | C | 0.1015693 |
| C | C | 0.2052441 |
| C | C | 0.2082710 |
| C | A | 0.1058486 |
| C | C | 0.2010231 |
| A | A | 0.0092764 |
| A | A | 0.0058992 |
| C | C | 0.2033106 |
| A | A | 0.0042265 |
| A | A | 0.0083598 |
| C | A | 0.1079429 |
| A | C | 0.1005901 |
| A | A | 0.0071879 |
| A | A | 0.0027791 |
| C | A | 0.1020563 |
| A | A | 0.0016369 |
| A | C | 0.1035759 |
| C | C | 0.2027799 |
| C | A | 0.1098044 |
| C | C | 0.2060675 |
| A | C | 0.1019345 |
| A | A | 0.0089523 |
| A | C | 0.1067570 |
| A | A | 0.0075206 |
| C | A | 0.1084945 |
| A | C | 0.1082591 |
| A | C | 0.1083380 |
| A | A | 0.0068559 |
| C | A | 0.1007404 |
| C | A | 0.1080892 |
| A | A | 0.0049616 |
| C | A | 0.1093175 |
| C | A | 0.1016522 |
| C | C | 0.2077733 |
| A | A | 0.0005095 |
| A | C | 0.1028709 |
| C | C | 0.2034431 |
| A | A | 0.0014703 |
| A | A | 0.0004128 |
| C | A | 0.1087299 |
| C | C | 0.2046786 |
| C | A | 0.1005526 |
| C | C | 0.2042106 |
| A | A | 0.0024032 |
| C | C | 0.2087338 |
| A | C | 0.1001473 |
| A | A | 0.0029913 |
| A | A | 0.0072218 |
| C | C | 0.2041333 |
| C | C | 0.2059208 |
| C | A | 0.1038899 |
| A | C | 0.1040284 |
| C | C | 0.2095852 |
| C | A | 0.1060037 |
| A | C | 0.1011649 |
| A | A | 0.0097105 |
| A | A | 0.0057150 |
| A | C | 0.1028203 |
| A | C | 0.1031190 |
| C | A | 0.1006120 |
| A | A | 0.0031889 |
| A | C | 0.1073314 |
| C | A | 0.1090091 |
| A | C | 0.1015117 |
| C | C | 0.2089782 |
| C | A | 0.1063983 |
| C | C | 0.2059702 |
| C | A | 0.1060347 |
| C | A | 0.1090694 |
| C | C | 0.2030218 |
| A | A | 0.0075704 |
| A | A | 0.0095580 |
| A | C | 0.1086542 |
| C | A | 0.1026623 |
| A | C | 0.1094137 |
| C | C | 0.2052773 |
| A | C | 0.1006339 |
| A | C | 0.1030232 |
| C | C | 0.2046393 |
| A | A | 0.0013274 |
| A | A | 0.0095300 |
| C | C | 0.2057215 |
| A | C | 0.1030079 |
| C | A | 0.1090685 |
| A | A | 0.0001077 |
| C | C | 0.2028376 |
| C | A | 0.1037775 |
| A | A | 0.0002552 |
| A | C | 0.1040291 |
| A | A | 0.0099021 |
| C | C | 0.2021005 |
| A | C | 0.1000609 |
| A | C | 0.1036054 |
| C | C | 0.2053793 |
| C | C | 0.2004941 |
| C | C | 0.2040068 |
| A | A | 0.0019378 |
| A | C | 0.1011605 |
| C | C | 0.2021554 |
| C | A | 0.1040450 |
| C | C | 0.2055633 |
| C | A | 0.1058654 |
| C | C | 0.2068447 |
| C | C | 0.2070774 |
| C | C | 0.2044591 |
| C | A | 0.1023905 |
| C | C | 0.2049679 |
| C | A | 0.1090468 |
| C | C | 0.2076719 |
| C | A | 0.1077369 |
| C | C | 0.2002493 |
| C | A | 0.1096146 |
| C | A | 0.1035319 |
| A | A | 0.0004373 |
| C | A | 0.1087651 |
| A | A | 0.0087918 |
| A | C | 0.1001747 |
| C | A | 0.1094938 |
| A | C | 0.1087396 |
| A | A | 0.0007139 |
| C | A | 0.1060227 |
| A | C | 0.1004070 |
| A | C | 0.1011735 |
| A | A | 0.0071202 |
| A | A | 0.0023324 |
| A | C | 0.1052538 |
| A | A | 0.0039247 |
| C | A | 0.1029682 |
| A | A | 0.0001661 |
| C | A | 0.1045111 |
| C | C | 0.2028671 |
| C | A | 0.1084758 |
| C | A | 0.1050526 |
| C | C | 0.2044098 |
| A | A | 0.0034096 |
| C | A | 0.1010419 |
| C | A | 0.1002349 |
| A | C | 0.1012938 |
| A | A | 0.0042111 |
| C | A | 0.1092317 |
| A | A | 0.0005314 |
| C | A | 0.1027641 |
| A | A | 0.0006976 |
| A | A | 0.0059262 |
| A | A | 0.0090875 |
| C | A | 0.1017007 |
| C | C | 0.2061476 |
| C | A | 0.1094093 |
| C | A | 0.1074382 |
| A | A | 0.0061305 |
| A | C | 0.1081789 |
| A | A | 0.0029955 |
| C | C | 0.2059311 |
| A | C | 0.1001573 |
| C | C | 0.2059439 |
| C | C | 0.2095260 |
| A | A | 0.0002275 |
| C | A | 0.1089683 |
| C | A | 0.1042173 |
| C | A | 0.1013811 |
| C | A | 0.1075982 |
| A | A | 0.0007373 |
| C | C | 0.2086883 |
| A | A | 0.0066158 |
| C | C | 0.2089862 |
| A | C | 0.1022184 |
| C | C | 0.2080956 |
| A | A | 0.0063738 |
| A | C | 0.1026643 |
| A | C | 0.1082529 |
| A | C | 0.1000397 |
| C | A | 0.1033214 |
| C | C | 0.2097367 |
| A | A | 0.0019888 |
| C | A | 0.1093363 |
| A | A | 0.0060884 |
| A | C | 0.1017966 |
| A | C | 0.1005280 |
| A | C | 0.1089720 |
| A | C | 0.1090451 |
| A | C | 0.1017959 |
| C | C | 0.2016410 |
| C | C | 0.2054955 |
| C | C | 0.2012397 |
| A | A | 0.0031768 |
| A | A | 0.0069890 |
| A | C | 0.1021115 |
| C | A | 0.1044951 |
| C | A | 0.1092024 |
| A | C | 0.1075797 |
| A | C | 0.1077012 |
| A | C | 0.1097675 |
| A | A | 0.0022042 |
| C | C | 0.2084285 |
| C | C | 0.2069840 |
| C | A | 0.1068630 |
| C | C | 0.2097429 |
| C | A | 0.1037399 |
| A | A | 0.0045708 |
| C | A | 0.1082478 |
| A | C | 0.1057078 |
| C | C | 0.2096548 |
| A | C | 0.1048772 |
| A | A | 0.0029792 |
| C | C | 0.2017846 |
| C | C | 0.2006963 |
| C | C | 0.2098875 |
| A | A | 0.0038926 |
| C | A | 0.1010932 |
| A | A | 0.0003468 |
| A | C | 0.1030456 |
| A | A | 0.0036705 |
| A | C | 0.1078713 |
| C | A | 0.1005561 |
| A | C | 0.1063571 |
| C | C | 0.2089823 |
| A | A | 0.0085762 |
| A | A | 0.0050809 |
| C | A | 0.1023808 |
| C | A | 0.1074656 |
| C | C | 0.2072080 |
| A | C | 0.1077854 |
| A | C | 0.1079360 |
| A | C | 0.1061646 |
| C | A | 0.1072907 |
| A | C | 0.1063067 |
| C | A | 0.1033325 |
| A | A | 0.0037981 |
| C | C | 0.2086743 |
| C | A | 0.1097386 |
| C | C | 0.2085420 |
| C | A | 0.1048677 |
| C | C | 0.2055260 |
| A | A | 0.0082194 |
| A | A | 0.0062467 |
| C | A | 0.1035184 |
| A | A | 0.0030221 |
| A | C | 0.1008503 |
| A | C | 0.1000136 |
| C | A | 0.1036397 |
| C | A | 0.1062002 |
| C | A | 0.1061710 |
| C | A | 0.1017129 |
| C | A | 0.1032231 |
| A | A | 0.0063761 |
| C | C | 0.2064750 |
| C | C | 0.2022226 |
| A | C | 0.1091733 |
| A | A | 0.0064618 |
| A | A | 0.0084215 |
| C | C | 0.2071592 |
| A | C | 0.1089278 |
| C | A | 0.1063172 |
| C | A | 0.1078012 |
| A | C | 0.1038597 |
| A | C | 0.1013259 |
| A | A | 0.0071703 |
| C | C | 0.2070604 |
| C | C | 0.2071973 |
| A | A | 0.0090835 |
| C | A | 0.1054635 |
| C | A | 0.1043283 |
| A | A | 0.0081247 |
| A | C | 0.1083681 |
| A | A | 0.0056144 |
| A | C | 0.1071056 |
| C | C | 0.2040757 |
| A | A | 0.0074696 |
| C | A | 0.1017408 |
| A | C | 0.1029973 |
| C | C | 0.2002477 |
| C | A | 0.1015532 |
| C | A | 0.1063173 |
| A | A | 0.0015141 |
| A | A | 0.0043867 |
| A | A | 0.0020748 |
| C | A | 0.1016015 |
| A | C | 0.1001028 |
| C | C | 0.2033488 |
| C | C | 0.2059610 |
| A | C | 0.1084401 |
| C | C | 0.2059321 |
| A | C | 0.1049264 |
| C | A | 0.1031694 |
| C | A | 0.1003591 |
| C | A | 0.1033975 |
| A | C | 0.1065793 |
| A | A | 0.0071433 |
| C | A | 0.1007311 |
| A | A | 0.0057025 |
| A | C | 0.1090507 |
| A | C | 0.1022610 |
| C | A | 0.1080890 |
| A | C | 0.1087481 |
| A | A | 0.0052728 |
| C | C | 0.2043440 |
| A | A | 0.0033352 |
| C | C | 0.2048579 |
| A | C | 0.1057698 |
| A | A | 0.0090046 |
| A | C | 0.1024363 |
| A | A | 0.0025662 |
| A | A | 0.0058716 |
| C | C | 0.2004678 |
| C | A | 0.1069020 |
| C | C | 0.2069458 |
| C | A | 0.1078559 |
| C | A | 0.1050637 |
| A | C | 0.1082012 |
| A | A | 0.0046341 |
| A | A | 0.0091965 |
| A | A | 0.0040570 |
| C | C | 0.2053070 |
| C | A | 0.1034255 |
| A | C | 0.1032237 |
| C | C | 0.2020856 |
| A | C | 0.1013295 |
| A | C | 0.1011642 |
| A | A | 0.0029731 |
| A | A | 0.0028415 |
| A | A | 0.0090742 |
| C | C | 0.2005457 |
| A | C | 0.1048641 |
| A | A | 0.0042378 |
| A | C | 0.1026630 |
| A | A | 0.0005094 |
| C | C | 0.2000952 |
| C | A | 0.1020843 |
| C | C | 0.2050337 |
| A | A | 0.0062792 |
| C | C | 0.2082651 |
| C | C | 0.2035859 |
| A | A | 0.0058338 |
| A | C | 0.1075437 |
| A | A | 0.0060577 |
| A | C | 0.1035764 |
| C | A | 0.1056779 |
| C | A | 0.1073068 |
| C | C | 0.2039563 |
| C | C | 0.2026859 |
| A | A | 0.0036335 |
| A | C | 0.1094857 |
| A | C | 0.1028160 |
| C | A | 0.1086489 |
| C | A | 0.1073270 |
| C | C | 0.2046995 |
| A | C | 0.1060796 |
| A | A | 0.0094262 |
| A | A | 0.0038777 |
| A | A | 0.0055042 |
| C | A | 0.1060838 |
| A | A | 0.0028996 |
| A | C | 0.1036533 |
| A | A | 0.0043957 |
| C | C | 0.2016006 |
| A | A | 0.0051138 |
| A | C | 0.1065655 |
| A | C | 0.1065747 |
| A | A | 0.0031585 |
| C | C | 0.2022020 |
| C | C | 0.2095778 |
| A | C | 0.1085457 |
| C | A | 0.1066143 |
| A | A | 0.0050391 |
| C | C | 0.2065038 |
| A | C | 0.1048536 |
| A | A | 0.0082425 |
| C | A | 0.1036056 |
| C | C | 0.2012939 |
| C | A | 0.1089108 |
| C | A | 0.1041844 |
| C | A | 0.1028691 |
| A | A | 0.0054941 |
| A | C | 0.1066732 |
| C | A | 0.1062203 |
| C | C | 0.2024171 |
| C | A | 0.1082409 |
| A | A | 0.0079531 |
| C | C | 0.2075896 |
| C | C | 0.2086618 |
| C | C | 0.2009030 |
| C | C | 0.2043583 |
| A | C | 0.1027433 |
| C | A | 0.1064741 |
| C | A | 0.1084550 |
| A | C | 0.1062956 |
| C | A | 0.1087552 |
| C | A | 0.1003688 |
| A | C | 0.1076954 |
| A | A | 0.0021614 |
| C | C | 0.2058926 |
| C | C | 0.2077966 |
| A | A | 0.0088255 |
| C | C | 0.2009546 |
| C | A | 0.1033496 |
| C | C | 0.2030929 |
| C | A | 0.1094367 |
| A | A | 0.0066950 |
| C | A | 0.1097632 |
| A | A | 0.0014252 |
| C | A | 0.1026898 |
| C | C | 0.2004895 |
| A | A | 0.0025115 |
| C | A | 0.1046488 |
| A | A | 0.0028188 |
| A | C | 0.1010309 |
| C | A | 0.1001824 |
| A | A | 0.0072118 |
| A | C | 0.1070029 |
| A | A | 0.0014907 |
| C | A | 0.1092398 |
| C | C | 0.2037578 |
| C | A | 0.1079571 |
| C | C | 0.2039170 |
| A | C | 0.1078900 |
| C | C | 0.2050323 |
| A | C | 0.1007074 |
| C | A | 0.1076159 |
| A | C | 0.1039099 |
| C | A | 0.1038567 |
| A | C | 0.1028247 |
| C | A | 0.1005284 |
| C | A | 0.1084924 |
| A | A | 0.0004356 |
| C | C | 0.2057357 |
| A | A | 0.0069600 |
| A | A | 0.0094913 |
| A | A | 0.0054146 |
| C | C | 0.2030491 |
| C | C | 0.2068785 |
| A | C | 0.1012664 |
| C | C | 0.2090525 |
| C | A | 0.1034316 |
| A | A | 0.0017198 |
| A | C | 0.1009245 |
| A | C | 0.1068556 |
| C | C | 0.2017306 |
| A | C | 0.1067565 |
| C | C | 0.2014062 |
| A | A | 0.0015376 |
| A | C | 0.1047583 |
| C | A | 0.1098352 |
| C | A | 0.1079203 |
| A | C | 0.1088965 |
| C | C | 0.2084315 |
| A | C | 0.1066086 |
| C | A | 0.1090615 |
| C | C | 0.2050194 |
| C | C | 0.2067315 |
| C | C | 0.2013299 |
| A | A | 0.0091168 |
| C | A | 0.1010853 |
| A | C | 0.1045174 |
| A | A | 0.0041893 |
| A | C | 0.1043304 |
| A | C | 0.1065061 |
| C | A | 0.1075389 |
| C | C | 0.2050606 |
| A | A | 0.0081449 |
| A | C | 0.1076916 |
| A | C | 0.1053452 |
| C | A | 0.1008132 |
| A | A | 0.0038407 |
| C | A | 0.1057814 |
| C | A | 0.1080700 |
| A | C | 0.1089578 |
| C | C | 0.2062821 |
| A | A | 0.0070441 |
| C | C | 0.2093743 |
| A | C | 0.1074053 |
| C | A | 0.1070470 |
| C | C | 0.2038438 |
| C | A | 0.1095235 |
| A | A | 0.0050486 |
| C | A | 0.1045503 |
| C | C | 0.2069982 |
| A | C | 0.1057359 |
| C | A | 0.1042752 |
| A | A | 0.0089466 |
| C | A | 0.1029824 |
| C | A | 0.1031178 |
| A | A | 0.0093870 |
| C | C | 0.2040780 |
| C | A | 0.1044772 |
| A | C | 0.1099405 |
| A | C | 0.1097643 |
| C | A | 0.1076331 |
| A | A | 0.0091503 |
| A | C | 0.1092546 |
| C | A | 0.1054719 |
| C | C | 0.2073775 |
| C | A | 0.1068021 |
| C | A | 0.1007462 |
| C | A | 0.1058175 |
| A | C | 0.1097546 |
| C | A | 0.1006635 |
| C | A | 0.1086204 |
| A | C | 0.1087185 |
| A | C | 0.1049784 |
| A | C | 0.1001977 |
| A | C | 0.1015302 |
| C | C | 0.2048015 |
| A | C | 0.1072400 |
| C | C | 0.2084621 |
| C | C | 0.2087810 |
| C | A | 0.1068725 |
| C | C | 0.2090149 |
| C | A | 0.1068327 |
| C | A | 0.1044658 |
| C | C | 0.2004135 |
| A | C | 0.1075305 |
| A | C | 0.1085318 |
| A | A | 0.0059603 |
| C | C | 0.2092286 |
| A | A | 0.0040192 |
| A | C | 0.1006736 |
| A | A | 0.0084393 |
| C | C | 0.2008492 |
| A | A | 0.0064031 |
| A | C | 0.1095494 |
| A | C | 0.1077496 |
| A | C | 0.1081119 |
| C | A | 0.1017594 |
| A | C | 0.1049967 |
| A | C | 0.1053113 |
| A | C | 0.1073927 |
| C | A | 0.1006140 |
| C | C | 0.2068344 |
| A | A | 0.0008224 |
| A | C | 0.1036102 |
| A | C | 0.1030666 |
| C | A | 0.1058666 |
| C | A | 0.1012143 |
| A | A | 0.0056010 |
| A | A | 0.0011629 |
| C | A | 0.1073621 |
| C | A | 0.1093461 |
| A | A | 0.0072568 |
| A | A | 0.0070607 |
| A | A | 0.0047138 |
| A | A | 0.0053748 |
| C | A | 0.1020702 |
| C | C | 0.2041623 |
| A | A | 0.0070479 |
| C | A | 0.1073771 |
| A | C | 0.1087822 |
| C | C | 0.2050439 |
| C | C | 0.2006254 |
| A | C | 0.1097647 |
| C | A | 0.1056063 |
| A | C | 0.1082803 |
| A | A | 0.0084556 |
| C | C | 0.2058733 |
| C | A | 0.1037796 |
| A | A | 0.0020639 |
| C | C | 0.2084784 |
| C | A | 0.1099888 |
| A | C | 0.1032313 |
| A | A | 0.0089915 |
| A | A | 0.0056860 |
| C | C | 0.2023480 |
| A | C | 0.1042078 |
| A | A | 0.0094923 |
| A | A | 0.0053080 |
| C | A | 0.1051261 |
| C | A | 0.1038632 |
| A | C | 0.1057118 |
| A | C | 0.1094236 |
| A | A | 0.0094175 |
| C | A | 0.1032157 |
| C | A | 0.1012338 |
| A | A | 0.0065028 |
| A | A | 0.0035082 |
| C | C | 0.2066001 |
| A | C | 0.1025485 |
| C | A | 0.1088288 |
| C | A | 0.1016259 |
| C | A | 0.1090762 |
| C | A | 0.1053571 |
| A | A | 0.0012706 |
| C | A | 0.1047291 |
| A | C | 0.1074995 |
| C | C | 0.2078383 |
| C | A | 0.1042556 |
| A | C | 0.1050666 |
| C | A | 0.1087901 |
| C | A | 0.1001518 |
| C | C | 0.2084834 |
| A | C | 0.1076047 |
| A | A | 0.0011402 |
| A | A | 0.0040615 |
| C | C | 0.2030513 |
| C | C | 0.2001287 |
| A | C | 0.1092634 |
| A | A | 0.0038775 |
| C | A | 0.1079434 |
| A | A | 0.0093957 |
| A | C | 0.1061099 |
| C | C | 0.2086783 |
| A | C | 0.1072238 |
| A | C | 0.1057325 |
| C | A | 0.1090037 |
| A | C | 0.1062527 |
| A | C | 0.1059294 |
| C | A | 0.1050627 |
| A | A | 0.0098811 |
| C | C | 0.2052331 |
| A | C | 0.1002454 |
| A | A | 0.0088222 |
| C | A | 0.1098436 |
| C | A | 0.1084630 |
| A | C | 0.1034789 |
| C | A | 0.1088481 |
| C | C | 0.2023805 |
| A | A | 0.0089221 |
knitr::kable(assoc_qt(additive_data))
| CHR | SNP | BP | NMISS | BETA | SE | R2 | T | P |
|---|---|---|---|---|---|---|---|---|
| 1 | snp_1 | 1 | 1000 | 0.1001 | 0.0001307 | 0.9983 | 766.1 | 0 |
Additive associations are detected awesomely!
Baron, Ronan, et al. “Elementary arithmetic operations by enzymes: A model for metabolic pathway based computing.” Angewandte Chemie International Edition 45.10 (2006): 1572-1576.
class: small-code
snvs <- create_snvs(
n_snps = 2,
n_individuals = 16
)
calc_xor_phenotype <- function(snvs) {
if (ncol(snvs) < 4) {
return(
rep(3.14, nrow(snvs))
)
}
0.1 * (snvs$snv_1a == snvs$snv_1b &
snvs$snv_1a != snvs$snv_2a &
snvs$snv_2a == snvs$snv_2b
)
}
snvs$xor <- calc_xor_phenotype(snvs)
knitr::kable(snvs)
| snv_1a | snv_1b | snv_2a | snv_2b | xor |
|---|---|---|---|---|
| A | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | A | C | A | 0.0 |
| A | A | C | C | 0.1 |
| A | C | A | A | 0.0 |
| A | C | A | C | 0.0 |
| A | C | C | A | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| C | C | A | A | 0.1 |
| C | C | A | C | 0.0 |
| C | C | C | A | 0.0 |
| C | C | C | C | 0.0 |
class: small-code
xor_trait <- create_custom_trait(
phenotype = "xor",
mafs = 0.49,
n_snps = 2,
calc_phenotype_function =
calc_xor_phenotype
)
xor_data <- create_demo_assoc_qt_params(
traits = xor_trait,
n_individuals = n_individuals
)
knitr::kable(
cbind(
xor_data$ped_table[, -seq(1, 6)],
xor_data$phe_table[, 3]
)
)
| snv_1a | snv_1b | snv_2a | snv_2b | xor |
|---|---|---|---|---|
| C | A | C | A | 0.0 |
| C | A | C | A | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| A | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| C | A | A | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | A | A | 0.0 |
| C | C | C | C | 0.0 |
| C | C | A | C | 0.0 |
| C | C | C | A | 0.0 |
| A | C | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | C | C | A | 0.0 |
| C | C | A | C | 0.0 |
| A | C | C | A | 0.0 |
| C | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| A | C | A | C | 0.0 |
| C | C | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | C | A | A | 0.0 |
| C | C | C | C | 0.0 |
| C | C | A | A | 0.1 |
| A | A | A | C | 0.0 |
| C | C | C | C | 0.0 |
| A | A | A | A | 0.0 |
| A | C | C | C | 0.0 |
| A | A | A | A | 0.0 |
| C | C | A | C | 0.0 |
| A | C | C | A | 0.0 |
| A | C | C | C | 0.0 |
| C | C | C | C | 0.0 |
| A | A | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| A | A | C | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| A | A | A | A | 0.0 |
| A | A | C | A | 0.0 |
| C | C | A | A | 0.1 |
| A | C | C | A | 0.0 |
| C | A | A | A | 0.0 |
| A | A | C | A | 0.0 |
| C | C | C | A | 0.0 |
| A | C | C | C | 0.0 |
| A | C | A | C | 0.0 |
| C | A | C | C | 0.0 |
| C | C | A | C | 0.0 |
| C | A | C | C | 0.0 |
| A | C | A | A | 0.0 |
| A | C | A | A | 0.0 |
| A | C | C | C | 0.0 |
| A | A | A | C | 0.0 |
| A | A | A | A | 0.0 |
| C | C | C | A | 0.0 |
| A | A | C | C | 0.1 |
| C | A | C | C | 0.0 |
| C | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | A | A | A | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| A | A | A | A | 0.0 |
| C | A | C | A | 0.0 |
| C | C | C | A | 0.0 |
| A | C | A | A | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| C | C | A | A | 0.1 |
| A | A | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | C | C | 0.0 |
| A | A | A | C | 0.0 |
| A | C | C | C | 0.0 |
| C | C | A | C | 0.0 |
| C | C | A | C | 0.0 |
| A | C | C | A | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | C | C | A | 0.0 |
| C | C | C | C | 0.0 |
| A | C | A | A | 0.0 |
| C | A | C | C | 0.0 |
| C | A | A | C | 0.0 |
| A | C | C | C | 0.0 |
| A | A | A | A | 0.0 |
| C | C | A | A | 0.1 |
| A | C | A | A | 0.0 |
| A | C | A | A | 0.0 |
| A | C | C | A | 0.0 |
| A | C | C | C | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | C | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | A | 0.0 |
| A | C | A | A | 0.0 |
| C | A | C | C | 0.0 |
| C | C | A | A | 0.1 |
| C | C | A | A | 0.1 |
| C | C | A | A | 0.1 |
| A | C | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| C | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| C | A | A | C | 0.0 |
| C | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| C | A | C | C | 0.0 |
| A | A | A | C | 0.0 |
| A | C | A | C | 0.0 |
| A | C | A | A | 0.0 |
| C | C | A | C | 0.0 |
| A | A | C | A | 0.0 |
| A | A | A | C | 0.0 |
| A | C | A | C | 0.0 |
| A | C | C | C | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| C | C | A | A | 0.1 |
| C | C | A | C | 0.0 |
| C | C | C | A | 0.0 |
| A | C | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| C | C | C | C | 0.0 |
| C | C | C | A | 0.0 |
| A | C | A | A | 0.0 |
| C | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | A | C | 0.0 |
| C | A | A | A | 0.0 |
| A | C | A | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | A | A | 0.0 |
| A | A | C | C | 0.1 |
| A | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| C | C | A | A | 0.1 |
| A | A | C | C | 0.1 |
| C | C | C | A | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| C | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| A | C | C | A | 0.0 |
| C | C | C | C | 0.0 |
| C | A | A | A | 0.0 |
| C | A | C | C | 0.0 |
| C | C | C | A | 0.0 |
| A | C | A | A | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| A | C | C | C | 0.0 |
| C | C | C | C | 0.0 |
| C | A | C | A | 0.0 |
| C | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | C | A | C | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| A | A | A | C | 0.0 |
| A | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| C | C | C | C | 0.0 |
| A | C | A | A | 0.0 |
| C | C | A | A | 0.1 |
| C | A | A | C | 0.0 |
| C | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| C | C | A | A | 0.1 |
| A | C | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | C | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | A | A | 0.0 |
| C | A | A | A | 0.0 |
| C | C | C | C | 0.0 |
| A | A | C | A | 0.0 |
| C | C | A | A | 0.1 |
| C | A | A | A | 0.0 |
| A | C | C | C | 0.0 |
| C | A | C | C | 0.0 |
| A | C | C | C | 0.0 |
| C | C | A | C | 0.0 |
| A | C | A | C | 0.0 |
| A | C | C | C | 0.0 |
| A | A | C | C | 0.1 |
| A | C | C | C | 0.0 |
| C | A | C | C | 0.0 |
| C | A | A | A | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | C | C | A | 0.0 |
| A | C | A | A | 0.0 |
| A | A | C | C | 0.1 |
| C | C | A | A | 0.1 |
| A | C | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | A | A | 0.0 |
| C | C | A | C | 0.0 |
| C | A | C | A | 0.0 |
| C | A | A | A | 0.0 |
| A | C | C | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | C | C | 0.0 |
| A | A | C | C | 0.1 |
| A | C | A | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| A | A | C | C | 0.1 |
| C | C | C | A | 0.0 |
| A | A | A | A | 0.0 |
| C | A | C | C | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| C | A | A | C | 0.0 |
| C | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| C | A | C | A | 0.0 |
| C | C | C | A | 0.0 |
| C | A | A | A | 0.0 |
| C | C | A | C | 0.0 |
| C | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| C | A | A | A | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| A | C | C | C | 0.0 |
| C | C | C | C | 0.0 |
| C | C | A | A | 0.1 |
| C | C | C | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | A | C | C | 0.0 |
| C | A | C | C | 0.0 |
| C | C | C | C | 0.0 |
| C | A | C | A | 0.0 |
| C | A | C | A | 0.0 |
| C | C | A | C | 0.0 |
| A | C | A | A | 0.0 |
| C | A | C | C | 0.0 |
| C | A | C | C | 0.0 |
| A | A | C | C | 0.1 |
| C | A | C | C | 0.0 |
| A | C | C | A | 0.0 |
| C | C | C | A | 0.0 |
| C | C | A | A | 0.1 |
| A | A | C | C | 0.1 |
| A | C | C | C | 0.0 |
| C | A | C | C | 0.0 |
| A | C | C | A | 0.0 |
| A | A | A | A | 0.0 |
| A | A | C | C | 0.1 |
| C | C | A | A | 0.1 |
| C | C | C | A | 0.0 |
| A | A | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | C | A | A | 0.1 |
| C | C | C | A | 0.0 |
| C | C | C | C | 0.0 |
| C | C | A | A | 0.1 |
| C | C | A | A | 0.1 |
| C | C | C | A | 0.0 |
| C | C | A | A | 0.1 |
| A | A | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | C | C | 0.0 |
| C | C | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | C | C | 0.0 |
| A | C | A | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| C | A | A | A | 0.0 |
| C | C | A | A | 0.1 |
| A | C | A | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | A | C | 0.0 |
| C | A | C | C | 0.0 |
| C | C | C | A | 0.0 |
| A | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| C | A | A | C | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | C | A | A | 0.1 |
| C | C | C | A | 0.0 |
| A | A | C | A | 0.0 |
| A | A | A | C | 0.0 |
| C | C | A | C | 0.0 |
| C | C | C | C | 0.0 |
| C | C | C | A | 0.0 |
| A | A | A | C | 0.0 |
| A | A | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | C | C | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | A | A | 0.0 |
| A | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | C | C | 0.1 |
| C | C | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | C | C | 0.0 |
| A | C | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| A | A | A | A | 0.0 |
| A | C | A | A | 0.0 |
| A | A | A | C | 0.0 |
| C | A | C | C | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| A | A | A | A | 0.0 |
| C | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| A | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| C | A | C | C | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| A | A | A | C | 0.0 |
| A | A | A | C | 0.0 |
| C | A | C | A | 0.0 |
| A | A | A | A | 0.0 |
| C | A | A | A | 0.0 |
| C | C | C | A | 0.0 |
| A | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| C | C | A | A | 0.1 |
| A | C | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | C | A | A | 0.1 |
| A | C | A | A | 0.0 |
| A | C | A | A | 0.0 |
| C | C | C | C | 0.0 |
| A | C | A | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | C | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | A | 0.0 |
| A | C | C | A | 0.0 |
| A | C | C | A | 0.0 |
| C | A | C | C | 0.0 |
| C | C | A | A | 0.1 |
| A | C | A | A | 0.0 |
| C | C | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| C | A | A | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | A | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | C | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | A | 0.0 |
| A | A | A | A | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | C | A | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | A | 0.0 |
| C | C | C | A | 0.0 |
| A | A | C | C | 0.1 |
| C | A | C | A | 0.0 |
| C | C | A | A | 0.1 |
| A | C | A | A | 0.0 |
| C | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | C | A | A | 0.0 |
| A | C | A | A | 0.0 |
| C | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| C | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | C | A | 0.0 |
| C | C | A | A | 0.1 |
| A | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| A | A | A | C | 0.0 |
| C | C | A | A | 0.1 |
| A | A | A | A | 0.0 |
| C | A | C | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| A | C | A | A | 0.0 |
| C | A | C | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | A | C | 0.0 |
| C | A | C | C | 0.0 |
| C | A | A | A | 0.0 |
| A | C | C | C | 0.0 |
| C | C | A | C | 0.0 |
| C | A | C | A | 0.0 |
| C | A | A | A | 0.0 |
| C | C | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | C | C | 0.1 |
| A | A | C | A | 0.0 |
| A | A | A | C | 0.0 |
| A | C | A | C | 0.0 |
| C | A | C | A | 0.0 |
| A | A | C | C | 0.1 |
| A | A | C | C | 0.1 |
| A | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| A | A | C | A | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| C | C | C | C | 0.0 |
| A | A | C | A | 0.0 |
| A | C | A | A | 0.0 |
| C | C | C | A | 0.0 |
| A | A | C | A | 0.0 |
| A | A | A | A | 0.0 |
| C | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| A | C | C | C | 0.0 |
| C | C | C | C | 0.0 |
| A | A | A | A | 0.0 |
| A | A | C | C | 0.1 |
| A | A | C | A | 0.0 |
| A | A | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| C | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | A | C | C | 0.1 |
| C | C | C | A | 0.0 |
| A | A | A | C | 0.0 |
| C | A | C | C | 0.0 |
| A | C | C | C | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | A | C | C | 0.1 |
| C | C | A | A | 0.1 |
| C | C | C | C | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| A | A | A | A | 0.0 |
| C | C | C | A | 0.0 |
| C | C | C | A | 0.0 |
| C | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | C | C | A | 0.0 |
| C | C | A | C | 0.0 |
| A | A | A | A | 0.0 |
| C | C | A | C | 0.0 |
| C | C | A | C | 0.0 |
| A | C | C | A | 0.0 |
| A | A | A | A | 0.0 |
| C | C | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | C | C | A | 0.0 |
| C | C | A | A | 0.1 |
| A | A | C | C | 0.1 |
| C | C | C | A | 0.0 |
| C | C | C | C | 0.0 |
| C | A | A | A | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | C | A | C | 0.0 |
| C | C | C | A | 0.0 |
| A | A | C | A | 0.0 |
| C | A | A | C | 0.0 |
| A | A | C | C | 0.1 |
| A | C | C | C | 0.0 |
| A | A | A | C | 0.0 |
| A | A | C | C | 0.1 |
| A | C | A | A | 0.0 |
| C | A | C | C | 0.0 |
| A | A | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | C | C | A | 0.0 |
| A | A | C | C | 0.1 |
| A | A | A | A | 0.0 |
| C | C | A | A | 0.1 |
| A | A | A | C | 0.0 |
| A | A | C | C | 0.1 |
| A | C | A | C | 0.0 |
| A | A | A | C | 0.0 |
| C | A | C | A | 0.0 |
| C | A | A | A | 0.0 |
| A | A | C | C | 0.1 |
| A | A | C | C | 0.1 |
| A | C | A | A | 0.0 |
| A | A | C | C | 0.1 |
| C | A | C | A | 0.0 |
| A | A | A | C | 0.0 |
| A | C | C | A | 0.0 |
| A | C | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | A | C | C | 0.1 |
| C | A | A | A | 0.0 |
| A | C | C | C | 0.0 |
| A | C | C | A | 0.0 |
| A | A | C | A | 0.0 |
| C | A | C | A | 0.0 |
| A | A | C | C | 0.1 |
| C | C | C | C | 0.0 |
| C | A | C | C | 0.0 |
| A | C | A | C | 0.0 |
| C | C | A | C | 0.0 |
| A | C | A | A | 0.0 |
| C | A | C | A | 0.0 |
| A | A | A | A | 0.0 |
| C | C | C | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | C | C | 0.1 |
| C | C | C | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| A | C | C | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| C | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| A | C | C | C | 0.0 |
| C | C | A | C | 0.0 |
| C | A | C | C | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | A | A | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| C | C | C | A | 0.0 |
| C | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| C | A | C | C | 0.0 |
| C | C | A | A | 0.1 |
| A | C | C | C | 0.0 |
| A | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| C | C | A | C | 0.0 |
| A | A | A | C | 0.0 |
| A | A | A | C | 0.0 |
| C | A | C | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | A | A | 0.0 |
| C | C | A | A | 0.1 |
| A | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | C | C | 0.1 |
| A | A | C | C | 0.1 |
| C | C | C | A | 0.0 |
| A | C | A | C | 0.0 |
| A | A | A | A | 0.0 |
| C | C | C | A | 0.0 |
| A | A | C | C | 0.1 |
| C | A | A | C | 0.0 |
| C | C | C | C | 0.0 |
| A | C | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | C | C | 0.0 |
| A | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | C | C | A | 0.0 |
| A | C | A | A | 0.0 |
| C | A | C | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | A | A | 0.0 |
| C | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| A | A | A | C | 0.0 |
| A | A | A | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | A | A | 0.0 |
| C | A | A | C | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| A | C | C | C | 0.0 |
| A | C | C | C | 0.0 |
| A | C | C | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| C | A | C | C | 0.0 |
| C | C | C | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | C | C | 0.0 |
| C | A | C | A | 0.0 |
| C | A | A | A | 0.0 |
| A | A | A | A | 0.0 |
| C | C | C | A | 0.0 |
| C | C | C | C | 0.0 |
| C | A | C | C | 0.0 |
| C | A | C | A | 0.0 |
| A | A | C | A | 0.0 |
| C | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| C | C | A | A | 0.1 |
| A | C | C | A | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| A | A | C | C | 0.1 |
| C | A | C | C | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | A | A | A | 0.0 |
| C | C | A | A | 0.1 |
| A | A | A | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | A | 0.0 |
| C | C | C | C | 0.0 |
| A | C | A | A | 0.0 |
| C | C | C | A | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| A | C | C | A | 0.0 |
| A | A | C | C | 0.1 |
| A | A | C | C | 0.1 |
| C | C | A | C | 0.0 |
| C | A | C | A | 0.0 |
| C | C | C | C | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | C | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | C | A | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | A | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| A | C | C | C | 0.0 |
| C | C | A | C | 0.0 |
| C | A | C | C | 0.0 |
| C | C | A | A | 0.1 |
| A | A | A | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | C | C | 0.0 |
| C | C | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | C | C | C | 0.0 |
| A | C | C | A | 0.0 |
| C | C | C | A | 0.0 |
| C | A | A | A | 0.0 |
| C | C | C | A | 0.0 |
| A | A | C | C | 0.1 |
| C | C | C | C | 0.0 |
| A | C | A | A | 0.0 |
| A | C | A | A | 0.0 |
| C | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| C | C | A | C | 0.0 |
| C | C | C | C | 0.0 |
| A | C | C | A | 0.0 |
| A | C | A | A | 0.0 |
| C | C | C | C | 0.0 |
| C | C | A | C | 0.0 |
| C | C | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | A | A | C | 0.0 |
| A | C | C | A | 0.0 |
| C | C | C | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | C | A | 0.0 |
| C | C | C | C | 0.0 |
| C | A | C | A | 0.0 |
| A | A | A | C | 0.0 |
| C | A | C | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| A | C | A | A | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | A | C | C | 0.1 |
| A | A | C | C | 0.1 |
| A | A | C | C | 0.1 |
| C | C | C | C | 0.0 |
| A | A | C | A | 0.0 |
| A | C | A | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | C | A | C | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| C | C | A | A | 0.1 |
| C | A | A | A | 0.0 |
| A | C | A | A | 0.0 |
| A | A | A | A | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | A | 0.0 |
| A | A | C | C | 0.1 |
| A | C | C | C | 0.0 |
| C | A | A | A | 0.0 |
| C | A | C | A | 0.0 |
| A | A | A | A | 0.0 |
| C | C | C | A | 0.0 |
| C | C | A | C | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| C | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | A | C | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | C | C | A | 0.0 |
| C | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| C | A | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | C | A | 0.0 |
| C | C | A | A | 0.1 |
| C | C | C | A | 0.0 |
| C | A | A | A | 0.0 |
| C | C | C | C | 0.0 |
| A | C | C | C | 0.0 |
| A | A | C | C | 0.1 |
| C | C | A | A | 0.1 |
| C | A | C | A | 0.0 |
| A | A | A | C | 0.0 |
| A | A | C | A | 0.0 |
| A | C | A | A | 0.0 |
| A | C | C | C | 0.0 |
| A | A | C | A | 0.0 |
| C | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | A | 0.0 |
| C | A | C | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| C | A | C | A | 0.0 |
| C | C | C | A | 0.0 |
| C | A | C | A | 0.0 |
| A | A | A | C | 0.0 |
| C | C | C | C | 0.0 |
| A | C | A | C | 0.0 |
| C | C | C | C | 0.0 |
| A | C | C | A | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| A | C | A | C | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| C | A | C | C | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | A | 0.0 |
| C | C | A | C | 0.0 |
| C | A | C | A | 0.0 |
| C | C | A | A | 0.1 |
| A | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | C | C | A | 0.0 |
| A | C | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | A | C | C | 0.1 |
| A | A | C | A | 0.0 |
| A | C | A | C | 0.0 |
| A | C | C | C | 0.0 |
| C | C | C | C | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | C | 0.1 |
| A | A | A | C | 0.0 |
| A | C | C | C | 0.0 |
| A | A | C | A | 0.0 |
| A | C | A | A | 0.0 |
| A | C | C | C | 0.0 |
| C | C | C | C | 0.0 |
| C | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | C | A | A | 0.0 |
| A | C | C | C | 0.0 |
| A | C | C | A | 0.0 |
| C | C | A | A | 0.1 |
| A | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| A | C | C | C | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| A | A | C | C | 0.1 |
| C | C | C | A | 0.0 |
| C | C | C | A | 0.0 |
| A | C | A | C | 0.0 |
| C | A | C | A | 0.0 |
| C | C | C | C | 0.0 |
| C | A | C | A | 0.0 |
| A | A | A | A | 0.0 |
| C | A | A | A | 0.0 |
| A | C | A | A | 0.0 |
| A | C | A | C | 0.0 |
| A | C | A | C | 0.0 |
| C | C | A | C | 0.0 |
| C | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| C | A | C | A | 0.0 |
| C | C | C | C | 0.0 |
| C | A | A | A | 0.0 |
| A | A | C | C | 0.1 |
| A | C | C | C | 0.0 |
| A | A | C | A | 0.0 |
| A | C | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| C | A | C | A | 0.0 |
| C | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| C | C | C | C | 0.0 |
| A | A | C | C | 0.1 |
| C | A | C | A | 0.0 |
| A | A | C | A | 0.0 |
| A | A | C | C | 0.1 |
| C | A | A | A | 0.0 |
| C | C | A | A | 0.1 |
| C | A | A | C | 0.0 |
| C | C | A | A | 0.1 |
| C | C | C | C | 0.0 |
| A | C | A | A | 0.0 |
| C | A | C | A | 0.0 |
| A | A | A | A | 0.0 |
| C | C | C | C | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | A | 0.0 |
| A | C | A | A | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| A | A | A | A | 0.0 |
| C | C | A | C | 0.0 |
| C | C | C | C | 0.0 |
| C | C | C | C | 0.0 |
| C | A | C | A | 0.0 |
| A | A | A | A | 0.0 |
| A | A | A | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | C | C | 0.0 |
| A | C | C | A | 0.0 |
| A | A | C | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | C | A | C | 0.0 |
| C | A | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | C | C | 0.1 |
| C | A | C | C | 0.0 |
| A | A | A | A | 0.0 |
| A | C | C | C | 0.0 |
| C | A | C | C | 0.0 |
| C | C | A | A | 0.1 |
| C | A | C | C | 0.0 |
| C | A | A | A | 0.0 |
| C | C | A | A | 0.1 |
| A | C | A | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | C | C | 0.0 |
| C | C | C | C | 0.0 |
| A | C | C | C | 0.0 |
| A | C | A | C | 0.0 |
| A | C | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | A | C | A | 0.0 |
| C | C | C | A | 0.0 |
| A | C | A | C | 0.0 |
| A | A | C | A | 0.0 |
| A | C | C | A | 0.0 |
| A | C | C | C | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | C | A | C | 0.0 |
| A | C | A | C | 0.0 |
| A | C | A | A | 0.0 |
| A | A | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | A | C | A | 0.0 |
| A | C | C | C | 0.0 |
| C | C | A | C | 0.0 |
| A | C | C | A | 0.0 |
| C | C | C | A | 0.0 |
| C | C | A | A | 0.1 |
| A | C | A | A | 0.0 |
| A | C | C | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | C | C | 0.0 |
| C | A | C | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | C | C | 0.0 |
| A | C | A | A | 0.0 |
| C | C | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | C | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | A | 0.0 |
| C | A | A | C | 0.0 |
| C | C | C | A | 0.0 |
| C | C | A | C | 0.0 |
| C | C | A | A | 0.1 |
| A | A | A | C | 0.0 |
| A | A | A | C | 0.0 |
| C | A | A | A | 0.0 |
| C | C | A | A | 0.1 |
| A | A | C | C | 0.1 |
| A | A | A | A | 0.0 |
| A | A | C | C | 0.1 |
| A | C | C | A | 0.0 |
| C | C | A | C | 0.0 |
| A | A | C | A | 0.0 |
| C | A | C | C | 0.0 |
| A | C | C | A | 0.0 |
| A | A | A | A | 0.0 |
| A | C | A | C | 0.0 |
| A | C | C | A | 0.0 |
| A | A | C | C | 0.1 |
| C | A | C | C | 0.0 |
| A | A | A | A | 0.0 |
| A | C | C | C | 0.0 |
| C | A | A | C | 0.0 |
| C | A | C | C | 0.0 |
| A | C | A | A | 0.0 |
| A | C | C | A | 0.0 |
| C | C | C | A | 0.0 |
knitr::kable(assoc_qt(xor_data))
| CHR | SNP | BP | NMISS | BETA | SE | R2 | T | P |
|---|---|---|---|---|---|---|---|---|
| 1 | snp_1 | 1 | 1000 | 0.0005299 | 0.001523 | 0.0001212 | 0.3479 | 0.7280 |
| 2 | snp_2 | 2 | 1000 | 0.0004813 | 0.001452 | 0.0001101 | 0.3315 | 0.7403 |
Exponential
class: small-code
snvs <- create_snvs(
n_snps = 3,
n_individuals = 16
)
calc_exp_phenotype <- function(snvs) {
as <- seq(1, ncol(snvs), by = 2)
bs <- as + 1
h <- snvs[, as] == snvs[, bs] & snvs[, as] == "C"
10 ^ rowSums(h)
}
snvs$exp <- calc_exp_phenotype(snvs)
knitr::kable(snvs)
| snv_1a | snv_1b | snv_2a | snv_2b | snv_3a | snv_3b | exp |
|---|---|---|---|---|---|---|
| A | A | A | A | A | A | 1 |
| A | A | A | A | A | C | 1 |
| A | A | A | A | C | A | 1 |
| A | A | A | A | C | C | 10 |
| A | A | A | C | A | A | 1 |
| A | A | A | C | A | C | 1 |
| A | A | A | C | C | A | 1 |
| A | A | A | C | C | C | 10 |
| A | A | C | A | A | A | 1 |
| A | A | C | A | A | C | 1 |
| A | A | C | A | C | A | 1 |
| A | A | C | A | C | C | 10 |
| A | A | C | C | A | A | 10 |
| A | A | C | C | A | C | 10 |
| A | A | C | C | C | A | 10 |
| A | A | C | C | C | C | 100 |
class: small-code
exp_trait <- create_custom_trait(
phenotype = "exp",
mafs = 0.49,
n_snps = 8,
calc_phenotype_function =
calc_exp_phenotype
)
exp_data <- create_demo_assoc_qt_params(
traits = exp_trait,
n_individuals = n_individuals
)
knitr::kable(
cbind(
exp_data$ped_table[, -seq(1, 18)],
exp_data$phe_table[, 3]
)
)
| snv_4a | snv_4b | snv_5a | snv_5b | snv_6a | snv_6b | snv_7a | snv_7b | snv_8a | snv_8b | exp |
|---|---|---|---|---|---|---|---|---|---|---|
| C | C | A | C | A | A | A | C | A | C | 1e+01 |
| A | A | A | C | A | A | C | A | C | A | 1e+00 |
| C | C | A | A | A | C | C | A | C | A | 1e+02 |
| A | C | A | C | C | C | A | C | C | C | 1e+03 |
| A | C | C | A | A | A | A | C | C | C | 1e+02 |
| C | C | C | A | C | C | C | A | A | A | 1e+02 |
| C | A | C | C | A | A | A | A | A | C | 1e+01 |
| A | A | C | C | C | A | C | A | C | A | 1e+01 |
| C | A | C | C | A | C | A | A | A | C | 1e+02 |
| A | C | C | C | A | C | A | C | A | A | 1e+03 |
| A | A | A | C | C | C | C | C | A | A | 1e+04 |
| A | C | C | A | A | A | A | C | A | C | 1e+00 |
| A | A | C | C | A | C | A | A | C | A | 1e+01 |
| C | C | C | C | C | C | A | A | C | C | 1e+04 |
| A | A | A | A | A | C | C | C | C | A | 1e+01 |
| A | C | C | A | A | C | A | C | C | C | 1e+02 |
| C | A | C | A | C | C | A | C | C | A | 1e+01 |
| A | A | C | C | A | C | C | A | A | A | 1e+01 |
| A | A | A | C | A | A | C | A | A | C | 1e+00 |
| A | A | A | C | C | A | C | A | A | C | 1e+01 |
| C | A | A | C | C | C | C | C | C | C | 1e+04 |
| A | A | C | C | C | A | C | A | C | C | 1e+02 |
| C | C | A | C | C | A | A | C | C | C | 1e+03 |
| A | C | A | A | C | C | C | A | A | A | 1e+02 |
| C | A | C | A | C | A | A | A | A | A | 1e+00 |
| A | A | C | C | C | A | C | A | A | C | 1e+02 |
| A | A | A | A | C | C | C | C | A | A | 1e+03 |
| C | A | A | C | A | A | C | A | A | A | 1e+01 |
| C | C | A | A | C | C | C | A | C | A | 1e+02 |
| A | A | C | A | C | A | A | C | A | C | 1e+00 |
| C | A | A | A | A | A | C | A | A | A | 1e+00 |
| A | C | A | A | A | A | C | C | C | A | 1e+01 |
| A | C | A | C | C | C | A | A | A | A | 1e+01 |
| A | A | C | C | A | A | C | A | C | A | 1e+01 |
| A | A | A | C | C | C | C | C | C | C | 1e+03 |
| C | C | A | A | C | C | C | C | A | C | 1e+04 |
| C | A | C | A | C | C | A | A | C | A | 1e+02 |
| C | A | C | C | A | A | C | C | A | C | 1e+03 |
| A | A | C | C | C | C | C | C | C | A | 1e+04 |
| C | C | C | A | C | A | A | A | A | A | 1e+02 |
| A | C | C | C | C | A | A | A | A | A | 1e+01 |
| A | A | C | A | A | A | C | C | A | C | 1e+01 |
| C | C | C | A | A | A | A | C | C | C | 1e+04 |
| A | C | C | C | C | C | A | A | A | C | 1e+04 |
| A | C | A | C | A | C | C | C | A | C | 1e+01 |
| A | C | A | A | A | A | A | A | A | A | 1e+01 |
| A | C | C | A | C | A | A | A | A | A | 1e+01 |
| C | C | A | A | A | A | C | A | A | A | 1e+01 |
| A | C | C | A | A | A | A | C | A | C | 1e+01 |
| A | C | A | C | C | C | C | A | C | A | 1e+02 |
| C | A | A | C | C | A | A | C | A | A | 1e+01 |
| C | A | C | A | A | C | C | C | C | C | 1e+02 |
| C | A | A | C | A | C | C | C | C | A | 1e+01 |
| A | C | C | C | C | A | A | A | C | C | 1e+02 |
| A | C | C | A | C | A | C | A | A | A | 1e+02 |
| C | C | C | C | A | A | A | C | C | C | 1e+04 |
| C | C | A | C | A | A | A | A | A | C | 1e+01 |
| A | A | A | A | A | A | C | C | A | A | 1e+01 |
| C | A | C | C | A | C | A | A | A | A | 1e+03 |
| C | A | C | C | C | C | C | A | C | C | 1e+04 |
| C | C | C | A | C | C | C | C | A | C | 1e+04 |
| C | C | A | C | C | A | A | C | A | A | 1e+02 |
| A | C | A | A | C | A | C | C | A | A | 1e+03 |
| A | A | C | A | C | A | C | C | A | A | 1e+02 |
| C | C | C | C | A | A | C | C | A | C | 1e+04 |
| C | A | C | A | C | C | A | C | A | A | 1e+01 |
| C | C | C | A | A | C | C | A | A | A | 1e+01 |
| A | C | C | C | C | A | C | A | C | A | 1e+01 |
| A | C | A | C | A | C | A | C | C | A | 1e+01 |
| A | A | C | C | C | C | C | C | A | A | 1e+03 |
| A | C | C | A | C | A | A | C | A | A | 1e+01 |
| C | A | A | A | A | C | A | A | C | A | 1e+01 |
| A | A | C | A | C | C | A | C | A | A | 1e+02 |
| A | A | C | C | A | A | C | C | A | C | 1e+02 |
| C | C | A | C | C | A | A | C | C | A | 1e+02 |
| C | C | C | C | A | C | C | A | A | A | 1e+03 |
| C | C | A | A | A | A | A | A | A | A | 1e+02 |
| C | C | C | A | C | C | C | C | C | A | 1e+03 |
| C | C | A | C | A | C | A | A | C | C | 1e+02 |
| A | A | A | A | A | A | A | A | C | C | 1e+01 |
| A | C | C | A | A | C | A | A | C | C | 1e+02 |
| A | C | C | C | A | A | A | C | A | C | 1e+03 |
| A | C | A | C | A | A | C | C | A | A | 1e+02 |
| C | A | C | A | A | A | C | C | C | A | 1e+01 |
| C | C | A | A | A | C | A | A | A | C | 1e+01 |
| C | A | A | A | C | C | C | C | C | C | 1e+04 |
| C | A | A | C | C | A | C | C | A | A | 1e+02 |
| C | A | A | C | A | A | C | C | A | A | 1e+02 |
| C | C | C | A | A | C | C | C | A | A | 1e+02 |
| C | C | A | C | A | C | A | A | C | A | 1e+01 |
| A | A | C | A | C | A | C | C | A | C | 1e+01 |
| C | C | A | A | C | A | C | A | A | A | 1e+01 |
| A | C | C | C | A | C | A | A | C | A | 1e+01 |
| C | C | A | A | C | C | A | A | C | A | 1e+03 |
| C | A | C | C | A | A | C | A | A | A | 1e+01 |
| A | C | A | C | C | A | A | A | A | A | 1e+00 |
| A | C | A | C | A | A | C | A | A | C | 1e+00 |
| A | C | C | C | C | C | A | C | C | C | 1e+03 |
| C | C | C | A | A | C | A | A | C | C | 1e+03 |
| A | A | C | C | C | A | C | A | C | A | 1e+01 |
| C | C | C | C | A | A | C | C | C | A | 1e+04 |
| A | A | C | C | C | A | C | A | A | C | 1e+02 |
| C | C | A | C | C | C | C | A | A | A | 1e+04 |
| C | C | C | A | A | C | A | A | C | C | 1e+03 |
| C | C | C | C | C | A | C | C | C | C | 1e+04 |
| A | A | A | A | A | A | C | A | C | C | 1e+01 |
| A | C | C | A | C | A | C | C | C | C | 1e+05 |
| C | C | A | A | C | A | A | A | A | A | 1e+01 |
| A | A | A | A | A | C | A | C | A | A | 1e+03 |
| A | C | C | A | A | A | C | C | C | C | 1e+03 |
| C | A | A | C | A | C | C | A | C | C | 1e+01 |
| A | C | C | A | C | C | A | C | A | A | 1e+02 |
| A | A | A | C | C | A | A | C | C | A | 1e+00 |
| C | A | A | A | A | A | C | C | A | C | 1e+02 |
| C | A | C | A | C | A | C | A | A | A | 1e+00 |
| C | A | C | C | C | C | C | A | A | C | 1e+04 |
| C | C | A | A | C | A | A | C | A | C | 1e+03 |
| A | A | C | A | A | A | C | A | A | A | 1e+00 |
| A | A | A | C | A | A | A | C | A | A | 1e+00 |
| C | A | C | C | A | C | C | A | C | A | 1e+01 |
| A | A | A | C | C | C | A | C | C | A | 1e+01 |
| A | C | A | C | A | C | C | A | A | A | 1e+00 |
| A | A | A | C | A | A | A | C | C | A | 1e+00 |
| C | A | A | A | A | A | C | C | A | A | 1e+03 |
| C | A | C | A | C | C | A | A | C | A | 1e+01 |
| C | C | C | A | A | A | C | C | C | C | 1e+03 |
| C | C | C | C | C | C | C | A | C | A | 1e+03 |
| A | C | C | C | C | A | A | C | C | C | 1e+04 |
| C | C | A | A | A | C | A | C | A | A | 1e+02 |
| A | C | A | C | C | A | A | C | A | C | 1e+01 |
| C | C | A | C | A | C | A | C | A | A | 1e+01 |
| C | C | A | A | C | C | A | C | A | A | 1e+02 |
| C | C | A | A | A | C | A | A | A | C | 1e+01 |
| C | C | C | A | A | C | C | A | C | A | 1e+03 |
| A | C | A | A | A | A | C | A | A | A | 1e+01 |
| A | C | A | A | C | A | C | A | C | A | 1e+00 |
| C | C | C | A | A | C | C | A | A | A | 1e+02 |
| A | C | A | C | A | C | A | A | A | A | 1e+01 |
| C | A | C | A | C | C | A | C | A | A | 1e+02 |
| C | A | C | C | C | A | A | C | A | A | 1e+01 |
| A | A | A | A | A | A | C | C | A | C | 1e+03 |
| C | C | A | A | C | C | C | A | A | C | 1e+03 |
| C | A | C | A | A | C | C | C | A | C | 1e+02 |
| A | A | C | A | C | A | A | C | A | C | 1e+01 |
| A | A | C | A | C | A | C | C | A | C | 1e+01 |
| A | A | A | A | A | A | A | C | C | A | 1e+02 |
| A | C | C | A | C | C | C | C | A | A | 1e+03 |
| A | A | A | A | C | C | A | C | A | C | 1e+02 |
| C | A | C | A | C | C | C | A | C | A | 1e+01 |
| C | C | C | C | A | A | A | A | C | A | 1e+02 |
| A | A | A | C | A | A | A | A | C | C | 1e+01 |
| C | A | A | A | C | C | C | C | C | C | 1e+04 |
| C | A | A | A | C | C | C | A | C | A | 1e+01 |
| C | A | A | A | C | A | C | A | C | C | 1e+01 |
| A | C | C | A | C | C | C | A | A | A | 1e+02 |
| A | A | A | C | A | A | C | C | A | C | 1e+03 |
| A | A | C | C | A | C | C | A | C | A | 1e+03 |
| A | C | C | A | A | A | A | A | A | C | 1e+02 |
| C | C | C | C | C | A | A | A | C | A | 1e+03 |
| A | C | A | A | C | A | A | C | C | C | 1e+02 |
| C | C | A | A | A | C | C | A | C | C | 1e+02 |
| C | A | A | C | C | A | A | A | C | A | 1e+02 |
| A | C | A | C | A | A | C | A | C | A | 1e+00 |
| A | C | C | C | C | C | C | A | C | C | 1e+06 |
| A | C | A | C | C | C | C | A | C | A | 1e+03 |
| C | C | C | C | C | C | A | A | C | C | 1e+05 |
| C | A | A | C | A | C | A | C | C | A | 1e+00 |
| C | C | A | C | A | A | C | A | C | A | 1e+02 |
| A | A | C | A | A | C | A | C | C | A | 1e+00 |
| A | C | C | A | C | C | A | C | C | A | 1e+03 |
| A | A | A | A | C | C | C | A | C | C | 1e+04 |
| A | A | C | C | A | A | C | A | C | A | 1e+01 |
| C | A | A | C | A | A | C | A | C | C | 1e+02 |
| C | A | C | A | C | A | C | C | C | A | 1e+01 |
| C | C | A | C | A | C | C | C | A | C | 1e+03 |
| C | A | A | A | A | A | C | A | A | C | 1e+01 |
| A | A | A | A | C | A | A | A | A | C | 1e+02 |
| A | A | A | C | A | A | A | C | A | A | 1e+01 |
| C | A | C | C | C | C | A | A | C | C | 1e+04 |
| A | C | C | A | C | A | C | C | A | C | 1e+03 |
| C | A | A | A | A | A | A | C | C | C | 1e+01 |
| A | A | C | C | A | C | C | A | A | C | 1e+02 |
| A | C | C | C | A | C | A | C | A | C | 1e+01 |
| C | C | C | C | C | A | C | A | A | C | 1e+03 |
| C | C | A | C | A | A | C | C | C | A | 1e+02 |
| C | A | A | A | A | A | C | A | C | A | 1e+00 |
| C | A | A | C | C | C | A | C | A | C | 1e+01 |
| C | C | A | C | C | C | C | C | A | A | 1e+05 |
| A | C | A | C | A | A | A | C | A | A | 1e+01 |
| C | C | C | A | C | C | C | C | A | C | 1e+03 |
| C | A | A | A | C | A | C | C | A | A | 1e+02 |
| A | C | C | C | C | A | C | C | C | C | 1e+05 |
| C | C | C | A | A | C | A | C | A | A | 1e+01 |
| C | C | A | C | A | A | A | A | A | A | 1e+01 |
| A | C | A | C | A | C | C | C | A | A | 1e+02 |
| A | A | A | C | C | A | C | C | C | C | 1e+03 |
| C | C | C | C | C | A | C | A | C | A | 1e+04 |
| C | A | C | C | A | A | A | A | A | C | 1e+01 |
| A | A | C | A | A | C | A | C | A | A | 1e+02 |
| A | A | A | A | A | A | A | A | C | C | 1e+02 |
| C | A | A | C | A | A | C | A | A | A | 1e+00 |
| C | C | A | A | C | A | C | C | A | C | 1e+02 |
| C | C | C | C | A | A | C | A | A | A | 1e+02 |
| C | A | A | A | A | A | C | A | C | A | 1e+00 |
| A | C | A | C | A | A | C | C | C | A | 1e+01 |
| A | A | C | C | A | A | A | A | C | A | 1e+01 |
| A | C | A | C | A | A | A | C | A | C | 1e+00 |
| C | C | A | A | A | A | C | A | A | A | 1e+02 |
| A | C | A | A | C | C | A | C | A | A | 1e+01 |
| C | A | C | A | A | C | A | A | A | A | 1e+01 |
| A | A | C | A | C | C | A | A | C | A | 1e+02 |
| A | C | C | C | C | C | A | A | A | A | 1e+02 |
| A | A | C | C | A | A | A | C | A | A | 1e+01 |
| A | C | C | C | C | C | A | A | A | A | 1e+03 |
| A | A | A | A | C | A | A | A | A | A | 1e+00 |
| C | C | A | A | C | C | C | C | C | C | 1e+06 |
| C | A | C | A | C | A | A | A | C | A | 1e+01 |
| A | A | C | C | C | C | A | A | A | A | 1e+02 |
| C | C | A | A | A | C | C | C | A | C | 1e+02 |
| A | C | A | C | A | C | C | A | C | A | 1e+00 |
| A | A | C | C | A | A | A | A | C | A | 1e+02 |
| C | A | C | A | C | C | A | C | C | A | 1e+01 |
| A | C | C | C | C | A | A | C | A | C | 1e+02 |
| A | A | A | C | A | A | A | A | C | C | 1e+01 |
| C | A | C | A | A | A | A | A | A | A | 1e+00 |
| C | C | C | C | C | C | C | A | C | C | 1e+04 |
| C | C | C | A | C | A | A | C | A | C | 1e+01 |
| C | A | A | A | A | A | A | A | A | A | 1e+00 |
| A | A | A | C | C | C | C | C | C | C | 1e+03 |
| C | A | C | A | C | C | C | C | A | A | 1e+05 |
| C | C | A | A | A | A | C | A | C | C | 1e+03 |
| A | C | C | A | A | C | C | C | A | A | 1e+03 |
| A | C | A | C | A | C | A | A | C | A | 1e+01 |
| A | C | A | A | A | C | C | C | C | A | 1e+01 |
| C | C | A | A | A | A | A | C | C | C | 1e+03 |
| A | C | A | C | A | A | C | A | C | A | 1e+01 |
| C | C | A | A | C | A | A | A | A | A | 1e+03 |
| C | C | C | A | C | C | A | A | C | C | 1e+03 |
| A | A | C | A | C | A | C | C | C | A | 1e+01 |
| C | A | C | A | A | A | C | A | C | A | 1e+01 |
| A | A | A | C | A | A | A | A | A | A | 1e+01 |
| C | A | C | C | A | C | A | A | C | A | 1e+02 |
| C | A | C | C | A | A | C | A | C | A | 1e+01 |
| A | A | A | C | C | C | C | A | C | A | 1e+01 |
| C | C | C | A | C | A | C | C | C | C | 1e+04 |
| A | C | A | C | A | C | C | A | C | A | 1e+01 |
| A | C | C | C | A | C | A | C | C | A | 1e+01 |
| C | A | C | A | C | C | C | C | A | C | 1e+03 |
| C | C | A | A | C | A | C | C | C | A | 1e+03 |
| A | C | A | C | A | A | A | A | A | C | 1e+01 |
| A | C | A | A | C | A | C | A | A | C | 1e+00 |
| C | C | A | A | C | C | C | A | A | A | 1e+04 |
| A | A | C | C | C | A | A | C | A | A | 1e+03 |
| C | C | A | C | A | C | A | C | A | C | 1e+02 |
| C | A | C | A | C | A | C | C | C | C | 1e+03 |
| C | C | C | A | C | A | A | A | C | C | 1e+02 |
| C | A | A | C | A | C | C | C | C | A | 1e+03 |
| C | A | A | A | C | C | A | C | C | A | 1e+01 |
| C | C | C | C | C | C | A | C | C | C | 1e+04 |
| A | A | C | C | A | C | C | A | C | C | 1e+02 |
| C | A | A | A | A | C | A | C | A | A | 1e+01 |
| A | C | C | A | A | C | C | A | A | C | 1e+01 |
| C | C | A | A | C | C | C | C | A | C | 1e+03 |
| A | C | C | C | A | A | C | C | A | C | 1e+03 |
| A | C | A | C | C | C | A | A | A | C | 1e+01 |
| A | A | C | C | A | A | C | A | A | C | 1e+02 |
| A | C | A | C | A | A | A | A | A | C | 1e+01 |
| A | A | A | C | C | C | C | C | C | C | 1e+04 |
| A | C | A | A | A | A | A | C | A | A | 1e+01 |
| C | C | C | C | C | C | C | C | C | A | 1e+05 |
| C | A | A | A | C | A | A | C | A | A | 1e+02 |
| A | C | C | C | C | A | A | C | A | C | 1e+03 |
| C | C | A | A | C | A | A | C | C | A | 1e+01 |
| C | C | C | C | C | C | C | C | C | A | 1e+04 |
| A | C | C | C | A | C | C | A | A | C | 1e+01 |
| A | A | A | A | C | A | A | C | C | A | 1e+00 |
| A | C | C | A | A | C | A | A | A | A | 1e+00 |
| C | C | C | C | A | C | C | C | A | A | 1e+04 |
| C | A | A | A | A | C | C | A | A | C | 1e+00 |
| A | A | A | A | A | C | C | C | A | C | 1e+01 |
| A | C | C | A | A | C | A | C | C | A | 1e+00 |
| C | A | A | C | A | C | A | C | C | C | 1e+02 |
| C | A | A | A | A | C | A | A | C | A | 1e+00 |
| C | C | A | C | A | C | A | A | A | A | 1e+03 |
| A | C | A | A | C | C | C | A | A | C | 1e+01 |
| C | A | A | A | C | A | A | C | C | A | 1e+01 |
| C | A | C | A | A | A | C | C | A | A | 1e+01 |
| A | A | C | C | C | A | A | C | C | C | 1e+03 |
| C | C | A | A | C | C | A | C | C | C | 1e+03 |
| C | A | C | A | A | A | C | A | A | C | 1e+01 |
| A | C | C | A | A | C | C | C | C | C | 1e+03 |
| A | A | C | A | A | A | A | C | C | C | 1e+01 |
| C | C | A | C | A | C | C | A | C | A | 1e+02 |
| C | A | A | A | A | C | C | A | A | C | 1e+01 |
| A | C | A | A | A | C | A | A | C | C | 1e+02 |
| A | C | A | C | A | C | A | A | C | A | 1e+03 |
| A | C | A | C | C | A | C | A | C | C | 1e+01 |
| A | C | A | C | A | C | A | A | A | A | 1e+01 |
| A | A | C | C | A | A | A | C | C | A | 1e+02 |
| C | A | C | C | C | C | C | A | A | C | 1e+03 |
| A | C | C | C | C | C | A | C | C | C | 1e+04 |
| C | A | A | C | C | A | C | A | A | A | 1e+01 |
| C | C | C | A | A | A | C | A | A | A | 1e+01 |
| C | A | A | A | A | C | C | C | A | A | 1e+01 |
| C | A | C | A | A | C | C | C | A | C | 1e+02 |
| A | C | A | A | A | C | C | C | C | C | 1e+03 |
| C | C | C | A | A | C | C | C | A | A | 1e+03 |
| C | C | C | A | A | C | A | A | A | A | 1e+01 |
| A | A | A | C | C | A | A | C | C | A | 1e+00 |
| A | C | A | C | A | C | A | A | C | A | 1e+01 |
| C | A | A | C | A | C | A | A | A | A | 1e+01 |
| C | A | A | C | C | A | A | C | C | C | 1e+03 |
| C | C | C | A | A | C | C | C | C | A | 1e+02 |
| A | C | C | A | C | A | A | A | A | C | 1e+00 |
| C | C | C | A | A | A | A | A | C | A | 1e+02 |
| A | A | A | C | C | C | A | A | C | A | 1e+02 |
| C | A | C | A | A | C | C | C | A | C | 1e+02 |
| C | A | C | A | A | A | C | C | C | C | 1e+04 |
| C | C | C | C | C | C | A | A | A | A | 1e+04 |
| C | C | C | A | A | C | A | C | A | C | 1e+02 |
| C | C | A | C | C | C | A | A | C | C | 1e+04 |
| C | C | A | C | C | C | C | A | C | C | 1e+03 |
| C | C | A | A | C | A | C | C | C | C | 1e+03 |
| C | A | A | A | A | C | C | C | C | A | 1e+02 |
| A | C | A | C | A | C | C | A | C | A | 1e+00 |
| C | A | A | A | A | C | A | C | A | A | 1e+02 |
| C | A | A | C | C | C | A | C | C | C | 1e+04 |
| C | C | C | C | A | A | A | A | A | C | 1e+03 |
| C | C | A | C | A | A | C | C | C | A | 1e+03 |
| C | A | C | C | A | C | C | C | C | C | 1e+04 |
| A | C | A | A | A | A | A | A | A | A | 1e+00 |
| C | A | A | C | A | A | A | A | A | C | 1e+01 |
| C | A | C | A | C | C | C | A | A | A | 1e+03 |
| A | A | A | A | A | A | C | A | C | C | 1e+02 |
| C | C | A | A | A | A | A | A | C | A | 1e+03 |
| C | A | C | C | A | C | C | C | A | A | 1e+03 |
| A | C | C | A | A | A | C | C | A | A | 1e+01 |
| C | C | A | A | C | A | C | A | C | C | 1e+03 |
| A | C | C | A | A | A | C | A | C | A | 1e+00 |
| A | C | C | C | C | A | A | A | C | C | 1e+03 |
| C | C | C | C | C | C | A | C | C | A | 1e+03 |
| C | C | C | A | A | C | A | C | A | C | 1e+01 |
| A | A | A | C | C | A | A | A | A | C | 1e+00 |
| C | C | C | A | A | C | A | A | A | A | 1e+01 |
| C | C | A | A | A | A | A | C | A | C | 1e+01 |
| C | C | C | A | A | A | A | A | C | A | 1e+01 |
| A | C | A | C | C | A | C | A | C | A | 1e+00 |
| A | C | A | C | A | A | C | C | C | A | 1e+02 |
| A | C | A | A | C | A | C | A | C | C | 1e+01 |
| A | A | A | C | A | A | C | C | C | A | 1e+01 |
| A | C | C | A | C | A | A | A | A | A | 1e+00 |
| C | C | C | C | A | A | A | C | A | C | 1e+03 |
| A | A | A | C | A | A | A | C | C | C | 1e+01 |
| C | C | A | C | C | A | C | A | A | C | 1e+02 |
| A | A | C | A | A | C | A | C | C | C | 1e+02 |
| A | C | A | A | A | C | C | A | A | C | 1e+01 |
| C | C | A | A | C | C | C | C | C | C | 1e+06 |
| C | C | C | A | C | A | C | C | A | A | 1e+02 |
| C | C | C | A | A | C | A | A | A | C | 1e+01 |
| A | A | A | C | A | A | A | A | C | A | 1e+00 |
| C | C | A | A | C | C | A | A | A | C | 1e+02 |
| C | C | A | A | A | A | A | C | A | C | 1e+02 |
| A | A | A | A | C | C | A | C | C | C | 1e+04 |
| A | C | A | A | C | C | C | C | C | A | 1e+04 |
| C | C | C | A | C | C | C | A | C | A | 1e+03 |
| C | C | C | C | A | C | A | C | C | C | 1e+04 |
| A | A | C | C | C | C | C | C | A | A | 1e+04 |
| C | C | C | C | C | A | A | A | A | C | 1e+02 |
| A | A | C | C | A | A | A | C | A | C | 1e+01 |
| C | A | C | A | A | C | A | C | C | C | 1e+01 |
| C | A | C | C | A | C | A | C | A | C | 1e+01 |
| A | A | C | A | C | C | A | C | C | A | 1e+02 |
| A | A | C | C | A | A | A | A | A | C | 1e+01 |
| A | C | C | C | C | C | C | C | C | A | 1e+03 |
| A | C | C | A | C | C | C | C | A | C | 1e+02 |
| A | C | A | A | A | A | A | C | C | C | 1e+01 |
| A | C | C | C | A | C | A | C | A | C | 1e+03 |
| C | A | A | A | A | C | A | A | C | A | 1e+00 |
| C | A | A | A | A | A | C | C | C | C | 1e+02 |
| C | C | A | C | C | A | C | C | C | A | 1e+03 |
| A | C | A | C | C | A | C | A | C | C | 1e+01 |
| C | A | C | C | A | A | A | A | A | A | 1e+01 |
| C | A | C | A | C | A | A | A | C | A | 1e+02 |
| C | C | A | C | C | A | C | C | C | A | 1e+02 |
| C | C | A | A | A | A | C | A | A | A | 1e+01 |
| A | A | A | A | A | A | C | A | C | C | 1e+02 |
| A | C | A | C | C | A | A | C | A | A | 1e+01 |
| A | A | C | A | C | C | C | A | C | A | 1e+02 |
| C | A | A | A | C | C | C | C | C | A | 1e+02 |
| C | C | A | A | C | A | C | C | C | C | 1e+03 |
| A | C | A | A | C | A | A | C | C | A | 1e+01 |
| A | A | A | A | A | C | A | A | A | C | 1e+02 |
| A | A | A | C | C | A | A | C | A | A | 1e+00 |
| A | A | A | A | C | C | C | C | A | A | 1e+03 |
| C | A | C | A | C | A | C | A | A | C | 1e+01 |
| C | C | C | A | C | A | C | C | C | A | 1e+04 |
| A | C | A | C | C | A | C | A | A | A | 1e+01 |
| C | C | A | C | A | C | A | A | A | A | 1e+01 |
| C | A | C | C | A | C | C | A | C | A | 1e+01 |
| C | A | A | C | A | C | A | C | C | A | 1e+02 |
| A | C | C | A | A | C | C | A | C | A | 1e+00 |
| C | A | C | C | C | A | C | A | C | C | 1e+02 |
| C | A | C | C | A | C | C | A | A | C | 1e+02 |
| C | A | C | C | C | A | C | C | A | A | 1e+02 |
| C | A | C | A | A | C | C | C | A | A | 1e+02 |
| C | A | A | C | A | A | A | A | C | C | 1e+02 |
| C | C | C | C | A | A | C | C | A | C | 1e+04 |
| A | C | C | C | C | C | A | A | C | A | 1e+04 |
| A | A | C | C | C | C | A | A | C | C | 1e+03 |
| A | C | C | C | C | A | A | C | C | A | 1e+01 |
| C | C | C | A | A | C | A | A | A | C | 1e+01 |
| C | A | C | A | C | A | C | A | A | A | 1e+01 |
| A | C | C | C | A | A | A | C | C | C | 1e+03 |
| C | C | A | A | A | C | C | C | A | C | 1e+02 |
| A | A | A | C | C | C | A | C | C | C | 1e+02 |
| A | A | A | C | A | C | A | C | C | C | 1e+01 |
| C | A | C | C | C | C | A | A | C | C | 1e+04 |
| C | A | A | A | C | A | A | C | C | A | 1e+02 |
| A | A | A | C | A | A | C | C | C | C | 1e+03 |
| C | A | C | A | C | C | C | C | C | A | 1e+04 |
| C | A | C | A | A | A | A | A | C | C | 1e+01 |
| A | A | A | A | A | A | A | C | A | A | 1e+01 |
| C | C | A | A | A | C | C | A | C | C | 1e+02 |
| A | A | C | A | C | C | A | C | C | A | 1e+03 |
| C | A | A | C | A | A | C | A | A | A | 1e+01 |
| C | C | A | C | C | A | C | A | C | C | 1e+02 |
| A | C | A | A | A | A | C | A | A | C | 1e+01 |
| A | A | C | C | C | C | C | C | A | C | 1e+05 |
| C | A | C | A | C | A | A | C | A | C | 1e+00 |
| C | A | C | A | C | A | A | A | C | C | 1e+01 |
| C | A | A | A | C | C | A | C | A | C | 1e+02 |
| C | A | C | A | C | C | A | A | C | A | 1e+02 |
| A | A | C | C | A | C | A | C | A | C | 1e+02 |
| C | A | A | C | A | A | A | C | C | A | 1e+00 |
| A | C | C | A | A | C | C | C | A | C | 1e+01 |
| A | C | C | A | C | A | C | C | C | C | 1e+05 |
| A | A | C | C | A | C | C | A | C | C | 1e+03 |
| A | C | A | C | C | A | A | A | C | C | 1e+01 |
| C | C | A | A | C | C | A | C | A | A | 1e+03 |
| C | A | A | A | A | A | C | C | A | A | 1e+02 |
| A | C | A | A | C | C | C | A | A | C | 1e+02 |
| A | C | A | C | C | A | A | A | A | C | 1e+00 |
| C | C | C | A | C | A | C | C | C | C | 1e+04 |
| A | C | A | A | C | A | C | C | C | C | 1e+02 |
| C | A | C | C | C | C | A | A | C | C | 1e+04 |
| C | C | A | C | C | C | A | C | A | A | 1e+03 |
| A | C | A | A | A | C | A | C | C | C | 1e+02 |
| A | A | C | A | A | C | C | A | A | A | 1e+00 |
| C | C | A | C | C | C | A | C | A | C | 1e+04 |
| C | C | C | A | A | C | A | C | A | A | 1e+02 |
| C | A | A | C | A | C | C | C | A | C | 1e+01 |
| C | A | C | C | C | C | A | A | A | A | 1e+02 |
| A | C | C | C | C | C | A | A | A | C | 1e+03 |
| C | C | C | A | A | C | A | C | A | A | 1e+02 |
| C | C | C | C | C | C | C | C | C | C | 1e+06 |
| C | A | A | A | A | C | C | C | C | A | 1e+01 |
| A | C | A | C | C | C | A | C | A | C | 1e+02 |
| A | C | C | C | C | A | C | C | C | A | 1e+03 |
| C | A | A | C | A | C | C | A | C | A | 1e+01 |
| C | A | C | A | C | A | C | C | A | C | 1e+02 |
| C | A | A | A | A | C | A | A | C | A | 1e+00 |
| C | A | A | C | C | A | A | C | C | A | 1e+00 |
| A | A | A | A | A | C | A | C | C | A | 1e+01 |
| A | C | C | A | A | C | C | C | C | A | 1e+01 |
| A | C | C | A | A | A | C | C | C | A | 1e+01 |
| C | C | A | A | A | A | A | A | A | A | 1e+03 |
| A | C | A | C | C | C | C | A | C | C | 1e+04 |
| C | A | A | C | A | A | A | A | C | A | 1e+00 |
| C | C | A | A | C | C | A | C | C | A | 1e+04 |
| C | A | A | A | A | C | C | A | A | C | 1e+00 |
| C | A | C | A | A | A | C | A | C | C | 1e+02 |
| C | A | A | C | C | C | A | C | A | A | 1e+01 |
| A | C | A | C | C | A | A | A | C | A | 1e+00 |
| A | C | C | C | C | C | C | A | C | C | 1e+03 |
| A | C | A | A | C | C | C | C | C | A | 1e+03 |
| A | C | A | A | C | A | C | A | C | C | 1e+02 |
| C | C | C | C | C | A | A | A | A | A | 1e+02 |
| C | C | A | C | C | A | A | A | A | A | 1e+01 |
| C | A | A | A | A | C | C | C | C | A | 1e+01 |
| A | A | C | A | A | C | C | C | C | C | 1e+03 |
| A | C | A | A | A | C | A | A | A | C | 1e+01 |
| A | A | A | C | C | C | C | A | A | C | 1e+01 |
| C | C | C | C | C | A | C | A | A | C | 1e+04 |
| A | C | A | A | C | C | A | C | C | C | 1e+02 |
| C | A | A | C | C | A | C | A | C | A | 1e+00 |
| A | A | A | C | A | C | A | A | C | A | 1e+00 |
| A | A | A | C | A | A | C | C | C | C | 1e+04 |
| A | C | A | C | C | A | C | A | C | A | 1e+01 |
| A | C | C | A | C | C | C | C | A | C | 1e+03 |
| A | A | C | A | A | A | A | A | C | A | 1e+00 |
| A | A | A | C | A | A | A | C | A | A | 1e+01 |
| C | A | C | A | A | C | A | A | A | A | 1e+00 |
| C | A | A | A | C | A | C | A | A | C | 1e+01 |
| A | A | A | A | A | C | C | C | A | A | 1e+03 |
| A | C | A | C | A | C | C | C | C | C | 1e+04 |
| A | A | A | C | C | A | C | C | A | C | 1e+02 |
| A | A | C | A | C | C | C | A | C | A | 1e+01 |
| C | C | C | C | C | C | A | A | A | C | 1e+03 |
| C | A | C | C | A | A | C | A | A | C | 1e+01 |
| C | C | C | A | A | C | A | A | A | C | 1e+01 |
| C | A | A | A | A | A | A | C | A | C | 1e+00 |
| C | C | C | C | A | C | A | A | A | C | 1e+03 |
| C | A | A | C | C | A | C | C | A | A | 1e+01 |
| C | C | C | C | C | C | C | C | A | A | 1e+05 |
| A | C | A | C | C | C | A | C | A | A | 1e+02 |
| C | C | A | C | C | A | A | A | A | A | 1e+02 |
| C | A | A | C | A | A | A | C | A | C | 1e+02 |
| A | A | C | A | C | C | A | C | A | C | 1e+01 |
| A | C | A | C | C | C | A | C | A | C | 1e+02 |
| C | A | A | A | C | C | C | C | A | C | 1e+04 |
| A | C | C | C | C | A | A | A | C | C | 1e+02 |
| A | A | C | A | C | C | C | C | C | C | 1e+05 |
| C | C | A | C | C | C | C | C | C | C | 1e+04 |
| C | C | C | A | C | A | C | C | A | C | 1e+02 |
| A | A | C | A | A | C | C | A | C | C | 1e+01 |
| C | C | C | A | A | C | A | C | C | A | 1e+02 |
| C | C | C | C | C | C | C | A | A | C | 1e+03 |
| A | A | A | C | C | C | A | A | A | C | 1e+01 |
| C | A | C | C | C | C | A | C | C | C | 1e+05 |
| C | C | A | A | A | C | A | C | C | C | 1e+03 |
| A | C | C | C | C | C | A | A | A | C | 1e+02 |
| C | C | A | C | A | C | A | C | C | C | 1e+03 |
| C | A | C | A | C | A | C | C | C | C | 1e+02 |
| C | C | A | C | C | C | C | A | C | A | 1e+02 |
| A | A | C | C | A | C | A | A | A | A | 1e+01 |
| A | A | A | A | A | C | A | C | C | C | 1e+01 |
| A | A | A | C | A | A | A | A | A | C | 1e+01 |
| A | C | A | A | A | A | A | A | C | A | 1e+02 |
| C | C | A | C | C | A | C | C | A | C | 1e+03 |
| C | C | C | C | C | C | A | C | A | A | 1e+03 |
| C | C | A | A | A | C | A | A | C | A | 1e+02 |
| C | C | C | A | A | C | A | A | C | C | 1e+02 |
| C | A | C | A | A | A | A | A | A | C | 1e+00 |
| C | C | A | C | A | C | A | C | C | C | 1e+03 |
| C | C | C | A | C | A | A | C | C | A | 1e+02 |
| A | A | A | A | C | C | C | C | C | A | 1e+02 |
| A | C | A | A | C | C | C | C | C | A | 1e+02 |
| A | C | C | A | C | C | C | C | A | A | 1e+04 |
| C | A | A | C | A | C | C | C | A | A | 1e+02 |
| C | C | A | A | C | A | C | A | C | C | 1e+02 |
| A | A | C | A | A | A | C | A | A | A | 1e+02 |
| C | C | A | C | C | C | C | A | C | C | 1e+03 |
| C | C | A | C | A | C | A | A | A | A | 1e+01 |
| A | A | A | C | C | A | A | A | C | A | 1e+01 |
| A | A | C | C | A | C | A | C | C | A | 1e+02 |
| A | A | A | C | C | A | A | A | A | C | 1e+00 |
| A | A | C | C | C | A | A | C | A | C | 1e+02 |
| A | A | A | C | C | A | C | C | A | C | 1e+02 |
| A | A | A | C | C | C | C | C | C | C | 1e+03 |
| A | C | C | C | C | C | C | A | C | A | 1e+04 |
| A | A | A | C | C | C | A | C | A | C | 1e+04 |
| C | A | C | C | C | C | A | A | C | C | 1e+04 |
| C | A | A | A | A | A | A | C | C | A | 1e+00 |
| C | A | A | A | C | A | C | C | A | C | 1e+01 |
| A | C | A | C | A | C | C | A | A | C | 1e+00 |
| C | A | C | C | A | C | C | A | A | A | 1e+02 |
| A | A | C | A | A | A | C | C | C | A | 1e+01 |
| C | A | A | A | A | A | C | A | C | A | 1e+01 |
| C | C | C | A | A | C | A | A | A | A | 1e+02 |
| C | A | C | C | C | A | A | A | C | A | 1e+02 |
| A | A | C | A | A | C | A | A | C | C | 1e+03 |
| A | C | A | A | A | C | A | C | A | A | 1e+01 |
| C | A | C | A | A | C | A | C | A | C | 1e+02 |
| C | C | A | C | A | C | A | A | A | C | 1e+01 |
| A | C | A | C | C | C | A | A | C | C | 1e+02 |
| C | C | A | A | A | A | A | C | A | A | 1e+03 |
| A | C | A | A | A | C | A | A | A | C | 1e+00 |
| C | C | A | C | C | A | C | C | C | C | 1e+03 |
| C | A | C | C | C | C | A | A | A | C | 1e+02 |
| C | A | C | C | A | A | A | A | A | C | 1e+02 |
| A | A | C | A | C | C | C | A | A | C | 1e+02 |
| C | A | C | A | C | A | A | A | C | A | 1e+00 |
| C | A | C | C | A | A | C | C | C | C | 1e+04 |
| A | C | A | A | C | A | C | A | C | A | 1e+00 |
| C | C | A | A | A | A | A | C | C | C | 1e+03 |
| C | C | C | C | A | A | A | A | A | C | 1e+02 |
| A | A | C | C | C | A | C | C | A | A | 1e+03 |
| C | A | C | C | A | A | A | C | A | A | 1e+02 |
| C | C | A | A | A | A | A | A | C | C | 1e+02 |
| A | A | A | C | A | C | C | C | C | C | 1e+03 |
| A | C | C | A | A | A | C | C | C | C | 1e+03 |
| A | C | A | C | C | A | C | A | A | A | 1e+00 |
| A | A | A | A | C | A | C | C | A | C | 1e+03 |
| C | A | C | A | A | A | C | A | A | A | 1e+01 |
| C | A | A | A | A | A | C | A | C | C | 1e+02 |
| A | A | C | C | C | C | A | C | C | A | 1e+02 |
| A | A | C | A | C | A | C | A | C | C | 1e+02 |
| C | C | A | A | C | C | A | C | A | C | 1e+02 |
| A | A | A | A | A | C | C | A | C | C | 1e+01 |
| C | C | A | A | A | C | C | C | C | C | 1e+03 |
| A | A | A | C | C | A | A | C | A | A | 1e+00 |
| C | C | A | C | C | C | A | C | A | C | 1e+02 |
| C | A | C | C | A | A | C | C | A | A | 1e+03 |
| A | C | C | C | A | A | A | C | A | A | 1e+02 |
| A | A | C | A | C | A | C | C | C | A | 1e+03 |
| A | C | A | C | A | C | C | C | C | A | 1e+03 |
| C | A | A | C | C | C | C | C | A | C | 1e+05 |
| C | A | A | C | A | A | A | A | C | A | 1e+01 |
| A | C | C | A | C | C | C | C | A | C | 1e+03 |
| C | C | C | C | A | A | C | A | C | C | 1e+04 |
| A | C | A | C | C | C | A | A | C | A | 1e+02 |
| C | C | C | C | C | C | A | C | A | C | 1e+03 |
| A | A | A | C | C | C | A | C | C | C | 1e+03 |
| C | C | A | A | A | C | C | A | A | C | 1e+02 |
| A | C | C | A | A | C | A | A | A | C | 1e+00 |
| C | C | C | A | A | C | A | A | C | A | 1e+02 |
| C | C | C | C | C | A | A | C | C | A | 1e+03 |
| C | A | C | C | C | A | C | A | A | A | 1e+02 |
| C | A | A | C | C | A | C | C | C | A | 1e+03 |
| A | C | C | C | A | C | C | C | A | A | 1e+02 |
| C | C | A | A | A | A | A | A | C | A | 1e+02 |
| C | C | C | A | C | C | C | C | A | C | 1e+04 |
| A | A | A | A | C | A | A | A | C | A | 1e+01 |
| C | C | A | A | A | A | A | A | C | A | 1e+01 |
| C | A | A | C | C | C | C | A | A | C | 1e+02 |
| A | A | A | C | A | C | A | A | A | C | 1e+00 |
| A | C | C | A | C | A | A | C | A | A | 1e+00 |
| A | A | A | C | C | A | A | C | C | A | 1e+00 |
| A | A | C | A | C | C | A | C | A | C | 1e+01 |
| A | C | C | A | C | C | C | C | A | C | 1e+03 |
| A | A | A | A | C | A | A | A | C | C | 1e+02 |
| A | A | A | C | C | A | C | A | A | A | 1e+00 |
| A | A | A | A | A | C | C | C | C | A | 1e+01 |
| C | C | A | C | A | A | A | A | A | A | 1e+02 |
| A | A | C | A | C | C | A | A | C | A | 1e+02 |
| A | C | C | C | C | C | A | A | A | C | 1e+03 |
| A | C | A | C | A | C | A | A | C | C | 1e+03 |
| A | A | A | A | C | A | A | C | A | C | 1e+01 |
| A | C | A | A | A | A | C | A | A | A | 1e+00 |
| C | A | A | A | A | A | C | A | C | A | 1e+00 |
| C | C | C | C | A | A | C | A | C | C | 1e+04 |
| A | A | A | A | C | C | A | C | C | A | 1e+02 |
| C | C | A | A | C | C | A | C | C | A | 1e+02 |
| A | A | C | C | C | C | C | C | C | C | 1e+05 |
| C | C | C | A | C | A | A | C | A | A | 1e+01 |
| A | A | C | A | C | C | C | A | A | A | 1e+01 |
| C | C | C | A | C | A | A | A | A | A | 1e+01 |
| C | A | A | C | A | A | C | A | A | C | 1e+02 |
| A | A | A | A | C | A | A | A | C | A | 1e+01 |
| C | C | A | A | C | A | A | A | C | A | 1e+01 |
| A | C | A | C | A | C | C | C | A | A | 1e+02 |
| A | C | C | C | C | A | C | A | A | A | 1e+02 |
| C | A | C | C | A | A | C | A | C | A | 1e+01 |
| A | C | A | A | A | A | C | A | C | C | 1e+02 |
| A | A | A | A | A | A | C | A | C | A | 1e+02 |
| A | A | A | A | A | A | A | C | C | C | 1e+01 |
| A | A | A | A | A | C | C | A | A | A | 1e+00 |
| A | A | C | C | C | A | A | C | A | C | 1e+01 |
| C | C | A | A | C | A | C | A | A | C | 1e+02 |
| A | A | C | C | A | C | A | A | A | A | 1e+02 |
| A | A | C | C | C | C | C | C | C | C | 1e+04 |
| A | A | C | C | A | C | C | A | C | C | 1e+02 |
| C | C | A | C | A | A | A | A | C | C | 1e+02 |
| A | C | A | C | A | A | C | C | C | C | 1e+04 |
| A | A | A | C | C | C | C | C | C | A | 1e+03 |
| A | A | C | A | C | A | A | C | A | A | 1e+00 |
| C | C | C | C | C | C | A | A | A | A | 1e+04 |
| A | A | C | A | C | A | C | A | C | C | 1e+01 |
| A | A | A | A | C | C | C | C | C | C | 1e+05 |
| A | C | A | C | A | C | A | C | A | C | 1e+00 |
| A | C | A | C | A | C | C | A | A | A | 1e+00 |
| C | C | A | C | A | A | A | A | A | C | 1e+03 |
| C | A | A | C | C | A | A | C | A | C | 1e+00 |
| C | A | A | C | A | C | A | A | C | A | 1e+00 |
| A | C | C | C | A | A | A | C | A | A | 1e+01 |
| C | A | A | C | C | C | C | C | A | C | 1e+03 |
| C | C | C | A | C | A | A | A | C | A | 1e+01 |
| C | C | C | A | A | C | C | A | A | A | 1e+01 |
| C | A | A | C | A | C | A | A | A | C | 1e+00 |
| A | A | A | C | C | C | C | C | A | C | 1e+03 |
| C | A | A | C | A | C | C | C | C | A | 1e+02 |
| C | A | A | C | C | C | A | C | A | A | 1e+03 |
| A | C | A | C | C | A | A | A | A | C | 1e+00 |
| C | A | A | C | C | A | A | A | C | C | 1e+02 |
| A | A | C | C | C | A | A | C | A | C | 1e+01 |
| A | A | C | A | A | C | A | A | A | A | 1e+02 |
| C | A | A | A | C | A | A | A | A | A | 1e+01 |
| C | A | C | C | C | C | C | C | A | C | 1e+04 |
| C | A | A | A | C | A | A | C | A | A | 1e+00 |
| C | C | A | A | A | A | C | A | C | C | 1e+02 |
| C | A | C | C | A | A | A | C | A | A | 1e+02 |
| C | A | A | A | C | C | C | C | C | C | 1e+03 |
| A | C | A | A | A | C | C | A | A | A | 1e+00 |
| C | C | A | A | A | A | A | C | A | A | 1e+02 |
| C | A | C | C | A | C | C | A | C | A | 1e+03 |
| C | C | A | A | A | A | C | C | A | C | 1e+02 |
| C | A | C | A | A | A | C | C | A | A | 1e+02 |
| A | A | C | A | A | A | A | C | A | A | 1e+00 |
| A | A | C | A | C | A | C | A | A | A | 1e+01 |
| A | C | A | C | A | C | A | A | A | C | 1e+01 |
| A | C | C | A | C | C | C | C | A | C | 1e+03 |
| C | C | A | C | A | A | C | C | C | C | 1e+03 |
| C | C | A | A | A | A | C | C | A | C | 1e+04 |
| A | A | C | A | A | C | A | A | A | A | 1e+01 |
| A | C | C | C | C | A | C | A | A | C | 1e+02 |
| C | C | A | A | A | A | A | C | C | C | 1e+04 |
| A | C | C | A | C | A | A | C | A | C | 1e+01 |
| A | C | A | A | C | C | A | C | C | A | 1e+03 |
| C | A | C | C | A | C | A | A | C | C | 1e+03 |
| C | A | C | C | C | A | A | C | A | C | 1e+02 |
| A | A | C | C | A | A | C | C | A | A | 1e+02 |
| C | C | A | A | A | C | A | C | C | A | 1e+01 |
| C | A | C | A | A | A | C | A | C | C | 1e+02 |
| A | A | A | A | C | C | A | C | A | C | 1e+02 |
| A | C | A | C | A | A | C | A | A | A | 1e+00 |
| A | C | C | A | C | A | A | A | A | C | 1e+01 |
| C | A | C | A | A | A | A | C | C | A | 1e+03 |
| A | C | C | C | C | C | C | A | A | C | 1e+02 |
| C | C | A | C | A | C | C | C | A | C | 1e+02 |
| C | C | C | C | C | A | C | A | C | C | 1e+04 |
| C | C | C | C | A | A | C | A | A | A | 1e+04 |
| C | C | C | A | C | A | C | A | A | A | 1e+02 |
| A | C | A | A | C | A | A | A | A | C | 1e+00 |
| C | A | A | C | C | C | C | C | A | A | 1e+04 |
| A | A | A | C | C | C | A | A | C | C | 1e+03 |
| C | A | C | A | C | A | A | A | A | C | 1e+01 |
| A | C | A | C | A | A | C | A | A | A | 1e+01 |
| A | C | A | A | C | C | C | A | C | C | 1e+02 |
| C | A | C | C | C | A | A | A | C | A | 1e+01 |
| C | C | A | C | A | A | A | C | C | A | 1e+03 |
| A | A | A | C | A | A | A | C | C | A | 1e+02 |
| A | C | A | A | C | C | A | A | C | A | 1e+01 |
| A | C | C | A | A | C | C | A | C | C | 1e+02 |
| A | C | C | A | C | C | C | A | A | C | 1e+03 |
| A | C | C | A | A | C | C | A | A | A | 1e+00 |
| C | C | A | A | A | A | C | C | A | C | 1e+03 |
| A | A | C | C | A | A | C | A | A | C | 1e+03 |
| C | A | A | A | A | C | C | A | A | C | 1e+01 |
| A | A | A | A | A | A | A | C | A | C | 1e+00 |
| A | A | C | C | A | C | A | A | C | C | 1e+03 |
| A | A | C | C | C | C | A | C | C | A | 1e+03 |
| C | C | A | C | C | A | C | C | C | C | 1e+04 |
| C | C | C | C | C | C | A | A | C | C | 1e+05 |
| A | A | A | A | C | A | C | C | C | C | 1e+02 |
| A | A | C | C | C | A | C | A | C | C | 1e+02 |
| A | C | A | C | C | C | A | A | C | A | 1e+03 |
| A | A | A | C | C | C | A | C | A | C | 1e+02 |
| A | A | C | A | A | A | A | C | C | C | 1e+01 |
| A | A | A | A | C | C | C | C | C | A | 1e+03 |
| A | C | A | A | A | C | A | C | A | C | 1e+00 |
| A | A | C | C | C | A | A | A | A | C | 1e+03 |
| C | A | C | C | C | C | C | A | C | A | 1e+03 |
| A | C | A | A | C | C | A | C | C | C | 1e+03 |
| A | A | C | C | C | C | C | A | A | C | 1e+03 |
| A | A | C | C | A | C | C | C | C | C | 1e+04 |
| C | A | C | A | C | C | A | C | C | C | 1e+03 |
| A | C | A | C | A | C | A | C | C | A | 1e+01 |
| A | A | A | C | A | C | A | C | A | A | 1e+01 |
| C | C | A | A | A | C | A | C | A | C | 1e+02 |
| C | A | A | A | A | C | A | C | C | A | 1e+01 |
| A | C | A | C | A | A | A | A | A | C | 1e+00 |
| A | C | C | C | A | C | C | C | C | C | 1e+03 |
| C | A | A | C | A | A | C | C | C | C | 1e+02 |
| A | C | C | A | C | C | A | C | C | C | 1e+03 |
| A | A | A | A | C | C | C | A | C | C | 1e+03 |
| A | A | A | A | A | A | C | A | C | A | 1e+01 |
| C | C | C | A | A | A | A | C | A | A | 1e+01 |
| A | A | C | A | C | C | C | C | A | A | 1e+03 |
| C | A | A | A | A | C | A | A | A | C | 1e+01 |
| A | A | C | A | C | C | C | C | A | A | 1e+02 |
| A | A | A | A | C | A | C | C | A | A | 1e+01 |
| C | A | A | A | C | A | A | A | C | C | 1e+01 |
| A | C | C | C | C | C | C | A | A | A | 1e+04 |
| A | A | A | A | C | C | A | A | C | C | 1e+03 |
| C | C | C | C | C | A | A | C | C | C | 1e+03 |
| C | A | C | C | A | A | A | A | A | C | 1e+01 |
| A | C | C | C | A | A | C | C | A | A | 1e+02 |
| A | A | A | A | C | C | A | C | C | C | 1e+02 |
| A | C | A | A | A | A | A | A | C | A | 1e+00 |
| C | A | A | A | A | A | C | A | A | C | 1e+00 |
| A | C | C | A | C | C | A | A | A | A | 1e+01 |
| A | C | C | C | A | A | A | C | A | C | 1e+01 |
| A | C | C | A | A | C | A | A | A | C | 1e+00 |
| C | C | A | A | C | C | C | A | A | C | 1e+04 |
| A | C | A | A | A | A | A | C | C | C | 1e+02 |
| C | A | A | A | C | A | A | C | C | C | 1e+02 |
| A | A | C | A | C | A | C | C | A | A | 1e+02 |
| A | A | C | A | A | C | A | C | A | A | 1e+02 |
| C | A | A | A | A | A | C | A | A | C | 1e+00 |
| A | A | A | C | A | C | A | A | A | C | 1e+01 |
| C | C | A | C | A | C | A | A | A | A | 1e+03 |
| A | A | C | A | C | A | C | A | A | C | 1e+01 |
| C | C | C | A | A | A | C | A | C | C | 1e+03 |
| A | A | A | C | A | A | A | C | A | C | 1e+01 |
| C | A | A | C | C | A | C | A | A | C | 1e+02 |
| A | C | A | C | A | A | C | C | C | A | 1e+03 |
| C | A | C | C | C | C | A | C | C | A | 1e+03 |
| A | A | A | C | A | A | C | C | C | C | 1e+02 |
| A | C | C | A | A | A | C | A | C | A | 1e+00 |
| C | A | C | A | C | A | C | A | A | A | 1e+01 |
| A | C | A | A | A | A | A | C | C | C | 1e+02 |
| A | A | C | A | C | A | A | A | C | C | 1e+02 |
| A | C | C | A | A | A | C | A | A | C | 1e+03 |
| A | C | C | A | C | A | A | C | A | C | 1e+00 |
| A | C | C | C | A | A | A | C | A | A | 1e+01 |
| C | C | C | C | A | C | C | A | A | A | 1e+03 |
| C | A | A | A | A | A | C | C | A | C | 1e+01 |
| C | A | A | A | C | A | C | C | A | A | 1e+04 |
| C | A | C | A | C | C | A | C | C | A | 1e+01 |
| A | A | C | C | C | C | C | A | A | C | 1e+03 |
| C | C | C | C | A | A | C | A | C | A | 1e+03 |
| A | C | C | C | A | C | A | C | C | A | 1e+01 |
| A | C | A | C | A | A | A | C | C | C | 1e+03 |
| C | A | A | C | A | C | A | A | A | C | 1e+01 |
| C | C | C | A | C | C | A | C | A | C | 1e+04 |
| C | A | C | C | C | C | A | C | A | A | 1e+03 |
| C | A | A | C | A | C | A | C | C | A | 1e+01 |
| A | C | C | C | C | C | A | C | C | A | 1e+03 |
| C | A | C | A | A | A | A | C | C | A | 1e+00 |
| A | C | C | A | A | A | C | C | A | A | 1e+03 |
| A | A | A | A | C | C | C | A | A | A | 1e+01 |
| A | A | C | A | C | C | A | C | A | A | 1e+02 |
| A | C | A | A | C | C | C | A | C | A | 1e+03 |
| A | C | A | A | A | A | A | A | C | A | 1e+02 |
| A | A | C | A | A | C | A | C | C | C | 1e+01 |
| A | C | C | A | C | C | A | C | A | C | 1e+01 |
| C | A | C | C | C | C | A | A | A | A | 1e+02 |
| C | A | C | A | C | A | C | C | C | C | 1e+02 |
| A | A | C | A | C | A | A | A | C | C | 1e+01 |
| C | A | C | C | A | A | A | A | C | A | 1e+02 |
| C | A | C | C | C | A | C | A | C | C | 1e+02 |
| A | C | A | A | C | A | A | C | C | A | 1e+01 |
| A | A | C | A | A | C | A | C | A | A | 1e+00 |
| A | C | A | A | A | A | C | C | A | C | 1e+01 |
| A | A | A | A | A | C | C | C | C | A | 1e+01 |
| A | C | C | C | A | A | A | A | A | C | 1e+02 |
| A | A | C | C | C | A | C | A | C | A | 1e+01 |
| A | A | C | A | A | C | A | A | A | A | 1e+01 |
| A | A | C | C | C | A | A | C | C | A | 1e+02 |
| A | A | A | A | C | C | C | A | C | A | 1e+02 |
| C | C | A | C | C | A | C | A | A | A | 1e+02 |
| A | C | C | A | A | A | C | A | A | A | 1e+00 |
| A | A | C | C | A | A | A | A | C | A | 1e+02 |
| A | C | A | A | C | A | A | A | C | A | 1e+00 |
| C | C | C | C | A | A | A | C | C | A | 1e+02 |
| A | A | A | A | A | C | C | A | A | C | 1e+01 |
| C | A | A | A | C | A | C | A | C | A | 1e+00 |
| C | A | A | A | A | A | C | C | A | C | 1e+01 |
| A | A | C | C | C | C | A | A | A | A | 1e+03 |
| C | A | A | A | C | C | C | A | A | A | 1e+02 |
| A | A | A | A | C | C | C | C | A | A | 1e+03 |
| C | C | A | C | A | C | C | C | C | A | 1e+03 |
| A | A | C | C | C | A | A | C | C | C | 1e+03 |
| A | A | C | C | C | A | A | A | C | C | 1e+04 |
| A | C | C | C | A | A | A | A | A | A | 1e+03 |
| A | A | C | C | C | C | A | C | C | C | 1e+04 |
| A | C | C | A | C | A | C | C | A | A | 1e+02 |
| A | C | A | A | C | C | C | C | C | C | 1e+04 |
| A | A | C | A | A | A | C | A | A | C | 1e+01 |
| A | A | C | C | C | C | C | C | A | C | 1e+04 |
| C | C | A | C | A | A | A | A | A | C | 1e+02 |
| A | A | A | A | C | C | A | C | C | C | 1e+03 |
| A | A | C | C | C | A | A | A | C | C | 1e+02 |
| C | C | C | C | C | A | C | A | C | A | 1e+02 |
| C | C | C | C | A | A | A | A | C | A | 1e+02 |
| C | A | C | C | A | A | A | C | C | C | 1e+02 |
| C | C | A | A | A | A | C | C | C | C | 1e+04 |
| C | C | A | C | C | C | C | A | A | C | 1e+04 |
| C | A | A | C | C | C | C | A | C | A | 1e+02 |
| A | A | A | A | A | C | A | C | C | C | 1e+03 |
| C | A | C | C | A | A | C | A | C | C | 1e+02 |
| A | C | A | A | C | C | A | C | C | A | 1e+01 |
| C | C | A | A | A | A | A | C | A | A | 1e+02 |
| C | A | A | A | A | A | A | A | A | C | 1e+01 |
| C | A | C | A | A | C | C | A | C | C | 1e+01 |
| C | A | A | A | A | C | A | A | C | A | 1e+01 |
| C | C | A | A | C | A | C | C | A | C | 1e+03 |
| A | A | A | A | A | A | C | C | C | C | 1e+03 |
| A | A | C | C | C | C | C | A | A | C | 1e+03 |
| C | C | C | C | A | A | A | A | C | C | 1e+03 |
| A | C | A | C | C | A | C | A | A | C | 1e+01 |
| A | C | A | C | A | C | C | C | C | C | 1e+03 |
| C | A | A | C | A | C | A | A | A | A | 1e+00 |
| C | A | C | C | C | A | C | A | A | A | 1e+02 |
| A | C | C | A | C | A | A | A | A | C | 1e+01 |
| A | C | A | A | A | C | A | C | A | A | 1e+00 |
| C | C | A | C | A | C | C | A | C | C | 1e+03 |
| A | A | C | C | C | A | A | A | C | C | 1e+02 |
| C | A | A | A | C | A | A | A | C | A | 1e+00 |
| A | C | A | C | A | A | A | A | A | C | 1e+01 |
| A | A | A | A | A | C | A | A | A | C | 1e+01 |
| A | A | C | C | A | C | C | C | C | A | 1e+03 |
| C | A | A | A | C | A | A | A | C | C | 1e+01 |
| C | A | A | A | A | A | C | A | A | A | 1e+00 |
| C | C | C | A | C | C | C | C | A | C | 1e+04 |
| A | A | C | A | A | C | A | C | A | C | 1e+01 |
| A | A | A | A | C | C | A | C | A | C | 1e+02 |
| A | C | A | A | A | A | C | C | A | A | 1e+01 |
| C | A | C | C | C | A | A | A | C | C | 1e+02 |
| A | C | C | A | C | A | A | A | A | A | 1e+00 |
| A | A | C | A | C | C | A | C | C | A | 1e+02 |
| C | C | C | A | C | A | C | A | A | C | 1e+01 |
| A | C | C | A | A | C | A | A | C | C | 1e+03 |
| A | C | C | C | A | A | A | C | C | C | 1e+04 |
| C | C | C | A | A | A | C | A | A | C | 1e+01 |
| A | A | A | A | C | C | A | C | A | A | 1e+01 |
| A | A | C | C | C | C | A | C | A | C | 1e+03 |
| C | C | C | A | A | A | C | A | A | C | 1e+02 |
| C | A | A | C | A | A | A | A | A | A | 1e+01 |
| C | C | A | A | A | A | A | C | C | C | 1e+03 |
| A | A | A | C | C | A | C | A | C | A | 1e+00 |
| C | A | C | A | C | A | C | A | A | C | 1e+00 |
| C | C | A | C | A | A | A | C | A | C | 1e+01 |
| C | C | C | C | C | C | A | C | A | A | 1e+03 |
| A | C | C | C | A | C | C | A | C | A | 1e+04 |
| C | C | A | C | C | C | A | A | A | A | 1e+03 |
| C | A | A | A | A | A | C | C | C | A | 1e+01 |
| A | A | C | C | A | A | C | A | A | C | 1e+03 |
| A | A | C | A | A | A | A | C | A | A | 1e+02 |
| A | C | C | C | A | A | C | C | C | A | 1e+03 |
| A | A | C | C | C | A | C | C | A | A | 1e+02 |
| C | A | A | A | A | C | C | C | C | A | 1e+01 |
| C | C | C | C | C | A | A | C | A | C | 1e+03 |
| C | A | A | A | C | C | C | C | C | C | 1e+04 |
| C | C | A | C | C | A | A | C | A | A | 1e+02 |
| A | C | C | C | A | A | C | C | C | C | 1e+03 |
| C | C | C | C | C | A | C | C | A | C | 1e+04 |
| A | C | A | A | A | C | C | A | C | A | 1e+01 |
| C | A | A | A | C | A | A | C | C | C | 1e+02 |
| A | A | A | C | A | A | A | A | A | A | 1e+00 |
| A | A | A | A | C | C | C | A | C | A | 1e+02 |
| C | A | A | A | A | A | A | A | C | C | 1e+02 |
| A | C | A | A | A | C | A | A | C | C | 1e+02 |
| A | A | A | A | A | A | A | A | A | A | 1e+00 |
| A | A | A | A | A | A | C | A | A | A | 1e+01 |
| C | C | C | A | C | C | C | A | C | A | 1e+02 |
| C | A | A | C | C | C | C | A | C | A | 1e+01 |
| C | A | C | A | A | A | C | A | C | A | 1e+01 |
| C | A | C | C | C | A | A | C | A | A | 1e+01 |
| C | C | C | A | C | C | A | A | C | A | 1e+03 |
| A | A | C | C | C | A | C | C | C | A | 1e+03 |
| C | A | C | C | A | C | A | A | C | C | 1e+02 |
| A | A | C | A | A | A | C | A | A | C | 1e+01 |
| A | A | C | C | C | A | A | A | C | C | 1e+03 |
| C | A | C | C | C | A | A | C | C | C | 1e+02 |
| C | A | A | C | C | C | C | C | A | C | 1e+02 |
| A | A | C | C | A | A | A | A | A | A | 1e+02 |
| A | A | A | C | A | C | C | C | A | C | 1e+03 |
| C | A | C | C | C | C | C | C | C | C | 1e+04 |
| C | A | C | A | C | C | A | A | A | A | 1e+01 |
| C | C | A | C | A | C | C | A | A | C | 1e+02 |
| C | C | C | C | A | A | C | A | A | C | 1e+03 |
| A | C | A | C | C | A | C | A | C | C | 1e+01 |
| A | A | C | A | A | C | C | C | C | C | 1e+02 |
| A | A | A | A | C | C | C | C | A | C | 1e+04 |
| A | C | A | C | A | C | A | A | A | C | 1e+00 |
| C | C | C | C | A | A | C | A | C | A | 1e+03 |
| A | C | A | A | A | A | A | A | C | A | 1e+01 |
| A | A | C | A | C | A | A | A | C | A | 1e+00 |
| C | A | C | A | C | A | A | A | C | C | 1e+01 |
| A | A | A | A | A | A | A | C | A | A | 1e+01 |
| A | A | C | C | A | A | A | A | A | A | 1e+01 |
| C | A | C | C | C | A | A | A | A | A | 1e+02 |
| A | C | C | A | A | C | A | C | C | A | 1e+01 |
| A | C | C | A | A | C | C | A | C | A | 1e+00 |
| C | A | C | A | C | A | C | C | A | A | 1e+01 |
| A | A | C | A | A | C | C | A | C | A | 1e+01 |
| A | C | A | C | A | A | C | A | C | A | 1e+00 |
| A | A | C | A | A | C | A | A | C | A | 1e+00 |
| C | C | A | A | C | C | A | C | C | A | 1e+02 |
| A | C | C | C | C | A | C | A | A | C | 1e+02 |
| A | A | C | A | A | C | C | A | A | C | 1e+01 |
| A | A | C | C | C | C | A | A | C | C | 1e+03 |
| A | A | C | A | A | A | A | A | A | C | 1e+00 |
| A | A | C | A | C | A | A | A | C | C | 1e+02 |
| A | C | A | C | A | A | A | C | A | C | 1e+01 |
| A | A | A | A | C | C | C | A | A | A | 1e+02 |
| A | C | C | C | A | C | A | C | C | A | 1e+03 |
| C | C | A | A | C | A | A | A | A | A | 1e+02 |
| C | A | C | A | A | A | C | C | A | C | 1e+03 |
| A | C | C | C | A | A | A | A | A | A | 1e+02 |
| C | C | A | A | C | A | A | C | C | A | 1e+01 |
| A | C | C | A | C | C | C | A | A | A | 1e+01 |
| A | A | A | C | A | A | C | A | C | A | 1e+00 |
| C | C | A | A | A | A | C | A | C | C | 1e+03 |
| C | C | A | C | C | A | C | A | A | A | 1e+02 |
| A | A | A | A | A | A | A | A | A | A | 1e+00 |
| A | A | C | A | A | A | A | C | C | A | 1e+01 |
| A | C | A | A | A | C | C | A | A | A | 1e+00 |
| C | C | A | C | C | C | A | A | C | C | 1e+04 |
| A | A | A | C | A | C | C | C | A | A | 1e+01 |
| C | C | C | A | C | C | C | C | A | C | 1e+04 |
| A | A | C | C | C | C | C | A | C | A | 1e+03 |
| A | A | C | C | C | C | A | C | C | A | 1e+03 |
| A | C | A | C | C | C | C | C | C | C | 1e+03 |
| C | C | C | C | A | A | A | A | C | C | 1e+05 |
| A | A | C | A | A | C | C | C | A | A | 1e+01 |
| C | C | C | C | C | C | A | A | C | A | 1e+03 |
| A | A | C | A | C | A | A | A | A | A | 1e+02 |
| C | A | A | C | C | A | C | C | C | C | 1e+05 |
| C | A | A | C | A | A | A | A | C | C | 1e+01 |
| C | A | A | A | C | C | C | A | A | A | 1e+01 |
| A | C | C | A | A | C | C | C | A | A | 1e+03 |
| C | C | A | C | A | A | C | C | C | A | 1e+03 |
| C | A | A | A | A | A | C | A | C | A | 1e+00 |
| A | A | C | C | C | A | A | C | C | C | 1e+03 |
| A | A | A | C | A | C | A | C | C | A | 1e+00 |
| C | C | A | C | A | C | A | A | A | A | 1e+03 |
| A | A | C | A | A | C | A | A | A | A | 1e+01 |
| A | A | C | A | C | C | C | C | A | C | 1e+02 |
knitr::kable(assoc_qt(exp_data))
| CHR | SNP | BP | NMISS | BETA | SE | R2 | T | P |
|---|---|---|---|---|---|---|---|---|
| 1 | snp_1 | 1 | 1000 | 8780 | 2889 | 0.0091700 | 3.0390 | 0.0024340 |
| 2 | snp_2 | 2 | 1000 | 4418 | 2881 | 0.0023510 | 1.5330 | 0.1255000 |
| 3 | snp_3 | 3 | 1000 | 8600 | 2866 | 0.0089410 | 3.0010 | 0.0027610 |
| 4 | snp_4 | 4 | 1000 | 7132 | 2836 | 0.0062980 | 2.5150 | 0.0120600 |
| 5 | snp_5 | 5 | 1000 | 2470 | 2861 | 0.0007464 | 0.8634 | 0.3881000 |
| 6 | snp_6 | 6 | 1000 | 10940 | 2802 | 0.0150400 | 3.9040 | 0.0001011 |
| 7 | snp_7 | 7 | 1000 | 9149 | 2882 | 0.0099980 | 3.1750 | 0.0015460 |
| 8 | snp_8 | 8 | 1000 | 10860 | 2888 | 0.0139800 | 3.7620 | 0.0001785 |
Enroth et al. “Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs.” Nature communications 5.1 (2014): 1-11.
Could you come up with
I’ll be happy try it!
?
| Publication model | Classical | Registered report |
|---|---|---|
| Significant results | Can publish | Can publish |
| No significant results | Cannot publish | Can publish |
Publication pressure was associated with higher odds of engaging frequently in ≥1 QRP (OR 1.22, 95% CI: 1.14, 1.30)